STEREOCHEMICAL DIFFERENTIATION OF ANTICONVULSANT AND ANTIHYPERTENSIVE EFFECTS IN 4-(FLUOROBENZOYLAMINO)BENZOPYRANS

被引：14

作者：

BLACKBURN, TP ^{[1
]}

BUCKINGHAM, RE ^{[1
]}

CHAN, WN ^{[1
]}

EVANS, JM ^{[1
]}

HADLEY, MS ^{[1
]}

THOMPSON, M ^{[1
]}

UPTON, N ^{[1
]}

STEAN, TO ^{[1
]}

STEMP, G ^{[1
]}

VONG, AK ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AW,ESSEX,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 11期

关键词：

D O I：

10.1016/0960-894X(95)00180-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Replacement of the 2-pyrrolidinone group of cromakalim 1 by the fluorobenzoylamino group has introduced anticonvulsant activity. It is particularly noteworthy that this activity is found predominantly in the 3R,4S enantiomeric series. In contrast, antihypertensive activity is restricted to the 3S,4R enantiomeric series.

引用

页码：1163 / 1166

页数：4

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