PREPARATION OF OLIGOMERIC 2'-DEOXY-5-FLUOROURIDYLATE OF DEFINED LENGTH AND BACKBONE COMPOSITION - A NOVEL PRO-DRUG FORM OF THE POTENT ANTICANCER DRUG 2'-DEOXY-5-FLUOROURIDYLATE

被引：10

作者：

GMEINER, WH

SAHASRABUDHE, P

PON, RT

SONNTAG, J

SRINIVASAN, S

IVERSEN, PL

机构：

[1] UNIV NEBRASKA,MED CTR,DEPT PHARMACEUT SCI,OMAHA,NE 68198

[2] UNIV NEBRASKA,MED CTR,DEPT PHARMACOL,OMAHA,NE 68198

[3] UNIV CALGARY,REG DNA SYNTH LAB,CALGARY,AB,CANADA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1995年 / 14卷 / 1-2期

关键词：

D O I：

10.1080/15257779508014667

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recursive protection scheme for FdUMP is employed by synthesizing oligonucleotides consisting of only FdU. 3'-O-exonuclease action releases FdUMP and a shortened oligonucleotide from which further exonuclease action releases more FdUMP. Such oligonucleotides are more cytotoxic to H4IIe, mouse fibroblast, and metastatic mouse tumor cells than are equivalent concentrations of FdU monomer.

引用

页码：243 / 253

页数：11

共 17 条

[1] A HOMOPOLYMER OF THE POTENT ANTI-TUMOR DRUG 2'-DEOXY-5-FLUOROURIDYLATE [J].