ANALOGS OF TETRAHYDROFOLIC ACID .39(1,2). SELECTIVE BROMOACYLATION OF POLYFUNCTIONAL MOLECULES FOR SYNTHESIS OF ACTIVE-SITE-DIRECTED IRREVERSIBLE ENZYME INHIBITORS

被引：46

作者：

BAKER, BR

SANTI, DV

COWARD, JK

SHAPIRO, HS

JORDAAN, JH

机构：

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1966年 / 3卷 / 04期

关键词：

D O I：

10.1002/jhet.5570030407

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

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页码：425 / &

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[1] ALKYLATION OF 2-AMINO-4-HYDROXYPYRIMIDINES WITH ACRYLONITRILE AND WITH DIMETHYL SULFATE - 2 PYRIMIDO[1,2-A]PYRIMIDINEDIONES
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[2] BAKER BH, TO BE PUBLISHED
[3] NON-CLASSICAL ANTIMETABOLITES .6. 4-(IODOACETAMIDO)-SALICYLIC ACID, AN EXO-ALKYLATING IRREVERSIBLE INHIBITOR
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[4] ANALOGS OF TETRAHYDROFOLIC ACID .10. SYNTHETIC + ENZYMIC STUDIES ON CONTRIBUTION OF P-AMINOBENZOYL-L-GLUTAMATE MOIETY OF PYRIMIDYL ANALOGS TO BINDING TO SOME FOLIC COFACTOR AREA ENZYMES
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[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1964, 7 (01) : 24 - &
[5] POTENTIAL ANTICANCER AGENTS .66. NON-CLASSICAL ANTIMETABOLITES .3. 4-(IODOACETAMIDO)-SALICYLIC ACID, AN EXO-ALKYLATING IRREVERSIBLE INHIBITOR OF GLUTAMIC DEHYDROGENASE
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[6] ANALOGS OF TETRAHYDROFOLIC ACID .8. SYNTHESIS OF N-[1-(2-AMINO-4-MERCAPTO-6-METHYL-5-PYRIMIDYL)-3-PROPYL]-P-AMINOBENZOYL-L-GLUTAMIC ACID, A MERCAPTO ANALOG
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[7] FACTORS IN DESIGN OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS
BAKER, BR
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (04) : 347 - &
[8] ANALOGS OF TETRAHYDROFOLIC ACID .24. FURTHER OBSERVATIONS ON MODE OF PYRIMIDYL BINDING TO DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE BY 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL TYPE OF INHIBITOR
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SANTI, DV
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (09) : 1252 - &
[9] SYNTHESIS OF 6-SUBSTITUTED PYRIMIDINES BY WITTIG REACTION .3. VIA 2-AMINO-4-HYDROXY-5-PHENULBUTYL-6-PYRIMIDYLMETHYL TRIPHENYL PHOSPHONIUM BROMIDE
BAKER, BR
JORDAAN, JH
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1966, 3 (03) : 324 - &
[10] ANALOGS OF TETRAHYDROFOLIC ACID .27. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE BY 2-AMINO-4,6-DISUBSTITUTED-5-ALKYLPYRIMIDINES AND 1-ALKYL-4,6-DIAMINO-1,2-DIHYDRO-S-TRIAZINES
BAKER, BR
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[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (10) : 1415 - &

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