DIASTEREOSELECTIVE CHLOROCYCLOFUNCTIONALIZATION OF N-ALLYLIC TRICHLOROACETAMIDES - SYNTHESIS OF AN ANALOG AND POTENTIAL PRECURSOR OF RP49532

被引：27

作者：

COMMERCON, A

PONSINET, G

机构：

[1] RHONE-POULENC SANTE - Centre de Recherches de Vitry-Alfortville 13, 94403 Vitry-sur-Seine Cedex

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 27期

关键词：

D O I：

10.1016/S0040-4039(00)97492-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of (E)-N-cinnamyl trichloroacetamide with hypochlorous acid yielded trans-dihydro-oxazine 8 which was easily hydrolyzed to (±)-erythro-β-chloro-γ-hydroxy- γ-phenyl-propanamine 2. Applied to the imidazole series, this chlorocyclization gave 15, a potential intermediate in the synthesis of RP49532. © 1990.

引用

页码：3871 / 3874

页数：4

共 13 条

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