NEUROPEPTIDE GENE-EXPRESSION AND NEURAL ACTIVITY - ASSESSING A WORKING HYPOTHESIS IN NUCLEUS CAUDALIS AND DORSAL HORN NEURONS EXPRESSING PREPROENKEPHALIN AND PREPRODYNORPHIN

被引：43

作者：

UHL, GR ^{[1
]}

NISHIMORI, T ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT NEUROL & NEUROSCI, BALTIMORE, MD 21224 USA

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 1990年 / 10卷 / 01期

关键词：

gene expression; in situ hybridization; molecular biology of peptidergic neurons; preprodynorphin; preproenkephalin;

D O I：

10.1007/BF00733637

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

1. The working hypothesis that neuropeptide gene expression in a neuron is an indicator of that neuron's physiological activity is discussed. 2. Representative examples from the literature are presented to support the hypothesis. 3. Further, we discuss the regulation of expression of two opioid peptides, preproenkephalin and preprodynorphin, in laminae I and II of the spinal cord and in nucleus caudalis of the trigeminal nuclear complex, where they may play a role in pain modulation. 4. The expression of the opioid peptide genes can be induced by both painful and nonnoxious stimuli in neurons in time-dependent and sensory-specific fashions. © 1990 Plenum Publishing Corporation.

引用

页码：73 / 98

页数：26

共 187 条

[1] ENDOGENOUS OPIOIDS - BIOLOGY AND FUNCTION [J].

AKIL, H ;

WATSON, SJ ;

YOUNG, E ;

LEWIS, ME ;

KHACHATURIAN, H ;

WALKER, JM .

ANNUAL REVIEW OF NEUROSCIENCE, 1984, 7 :223-255

[2] INVITRO TRANSCRIPTION DIRECTED FROM THE SOMATOSTATIN PROMOTER IS DEPENDENT UPON A PURIFIED 43-KDA DNA-BINDING PROTEIN [J].

ANDRISANI, OM ;

ZHU, Z ;

POT, DA ;

DIXON, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) :2181-2185

[3] REDUCTION OF STRIATAL DOPAMINERGIC NEUROTRANSMISSION ELEVATES STRIATAL PROENKEPHALIN MESSENGER-RNA [J].

ANGULO, JA ;

DAVIS, LG ;

BURKHART, BA ;

CHRISTOPH, GR .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 130 (03) :341-343

[4]

ARONIN N, 1981, J NEUROSCI, V1, P561

[5] A QUANTITATIVE STUDY OF THE EFFECTS OF NEONATAL CAPSAICIN TREATMENT AND OF SUBSEQUENT PERIPHERAL-NERVE TRANSECTION IN THE ADULT-RAT [J].

ARVIDSSON, J ;

YGGE, J .

BRAIN RESEARCH, 1986, 397 (01) :130-136

[6] ENHANCERS - MECHANISMS OF ACTION AND CELL SPECIFICITY [J].

ATCHISON, ML .

ANNUAL REVIEW OF CELL BIOLOGY, 1988, 4 :127-153

[7] COORDINATE HORMONAL AND SYNAPTIC REGULATION OF VASOPRESSIN MESSENGER-RNA [J].

BALDINO, F ;

OKANE, TM ;

FITZPATRICKMCELLIGOTT, S ;

WOLFSON, B .

SCIENCE, 1988, 241 (4868) :978-981

[8] HORMONAL-REGULATION OF SOMATOSTATIN MESSENGER-RNA [J].

BALDINO, F ;

FITZPATRICKMCELLIGOTT, S ;

OKANE, TM ;

GOZES, I .

SYNAPSE, 1988, 2 (03) :317-325

[9]

BALDINO F, 1986, HYBRIDIZATION BRAIN, P97

[10] ORIGIN, DISTRIBUTION AND SYNAPTIC RELATIONSHIPS OF SUBSTANCE-P AXONS IN RAT SPINAL-CORD [J].

BARBER, RP ;

VAUGHN, JE ;

SLEMMON, JR ;

SALVATERRA, PM ;

ROBERTS, E ;

LEEMAN, SE .

JOURNAL OF COMPARATIVE NEUROLOGY, 1979, 184 (02) :331-351

← 1 2 3 4 5 6 7 8 9 10 →