CONGENITAL HEART-BLOCK WITH HYDROPS-FETALIS TREATED WITH HIGH-DOSE DEXAMETHASONE - A CASE-REPORT

被引：11

作者：

CHUA, S ^{[1
]}

OSTMANSMITH, I ^{[1
]}

SELLERS, S ^{[1
]}

REDMAN, CWG ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP,DEPT PAEDIAT,OXFORD OX3 9DU,ENGLAND

来源：

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 1991年 / 42卷 / 02期

关键词：

CONGENITAL HEART BLOCK; HYDROPS-FETALIS; DEXAMETHASONE;

D O I：

10.1016/0028-2243(91)90176-L

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A 32-year-old woman with systemic lupus erythematosus was found to have a fetus with heart block and fetal ascites at 23 weeks gestation. Treatment with high-dose corticosteroids ameliorated the early signs of heart failure, although the fetal heart rate gradually fell from 48 beats/min to 42 beats/min by 34 weeks. Sudden deterioration of the fetal state occurred at 35 weeks, and this only partially responded to digitalisation. Neonatal death occurred on Day 18 from the consequences of severe birth asphyxia. The relationship and pathogenesis of anti-Ro antibodies, congenital heart block and hydrops fetals are discussed, together with the in utero management of this condition.

引用

页码：155 / 158

页数：4

共 11 条

[1] FETAL HYDROPS AND CONGENITAL COMPLETE HEART-BLOCK - RESPONSE TO MATERNAL STEROID-THERAPY [J].

BIERMAN, FZ ;

BAXI, L ;

JAFFE, I ;

DRISCOLL, J .

JOURNAL OF PEDIATRICS, 1988, 112 (04) :646-648

[2] INVITRO METABOLISM OF PREDNISOLONE, DEXAMETHASONE, BETAMETHASONE, AND CORTISOL BY HUMAN PLACENTA [J].

BLANFORD, AT ;

MURPHY, BEP .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1977, 127 (03) :264-267

[3]

BUYON J, 1988, J RHEUMATOL, V15, P1104

[4] INTRAUTERINE THERAPY FOR PRESUMPTIVE FETAL MYOCARDITIS WITH ACQUIRED HEART-BLOCK DUE TO SYSTEMIC LUPUS-ERYTHEMATOSUS - EXPERIENCE IN A MOTHER WITH A PREDOMINANCE OF SS-B (LA) ANTIBODIES [J].

BUYON, JP ;

SWERSKY, SH ;

FOX, HE ;

BIERMAN, FZ ;

WINCHESTER, RJ .

ARTHRITIS AND RHEUMATISM, 1987, 30 (01) :44-49

[5] ASSOCIATION OF MATERNAL SYSTEMIC LUPUS-ERYTHEMATOSUS WITH CONGENITAL COMPLETE HEART-BLOCK [J].

CHAMEIDES, L ;

TRUEX, RC ;

VETTER, V ;

RASHKIND, WJ ;

GALIOTO, FM ;

NOONAN, JA .

NEW ENGLAND JOURNAL OF MEDICINE, 1977, 297 (22) :1204-1207

[6] FETAL ASCITES AND CONGENITAL HEART-DISEASE [J].

FEENEY, JG .

BRITISH MEDICAL JOURNAL, 1981, 283 (6297) :934-935

[7] RO (SS-A) ANTIBODY AND ANTIGEN IN A PATIENT WITH CONGENITAL COMPLETE HEART-BLOCK [J].

HARLEY, JB ;

KAINE, JL ;

FOX, OF ;

REICHLIN, M ;

GRUBER, B .

ARTHRITIS AND RHEUMATISM, 1985, 28 (12) :1321-1325

[8] CONGENITAL HEART BLOCK AND WIDESPREAD FIBROSIS DUE TO MATERNAL LUPUS ERYTHEMATOSUS [J].

HULL, D ;

BINNS, BAO ;

JOYCE, D .

ARCHIVES OF DISEASE IN CHILDHOOD, 1966, 41 (220) :688-&

[9] MATERNAL CONNECTIVE-TISSUE DISEASE AND CONGENITAL HEART-BLOCK - DEMONSTRATION OF IMMUNOGLOBULIN IN CARDIAC TISSUE [J].

LITSEY, SE ;

NOONAN, JA ;

OCONNOR, WN ;

COTTRILL, CM ;

MITCHELL, B .

NEW ENGLAND JOURNAL OF MEDICINE, 1985, 312 (02) :98-103

[10] FETAL BIOPHYSICAL PROFILE SCORING - A PROSPECTIVE-STUDY IN 1, 184 HIGH-RISK PATIENTS [J].

MANNING, FA ;

BASKETT, TF ;

MORRISON, I ;

LANGE, I .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1981, 140 (03) :289-294

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