CHEMICAL CLEAVAGE OF PLASMID DNA BY CU(II), NI(II) AND CO(III) DESFERAL COMPLEXES

被引：30

作者：

JOSHI, RR ^{[1
]}

GANESH, KN ^{[1
]}

机构：

[1] NATL CHEM LAB,DIV ORGAN CHEM,BIOORGAN CHEM UNIT,POONA 411008,MAHARASHTRA,INDIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91773-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is demonstrated that the Cu(II), Co(III) and Ni(II) complexes of a siderophore chelating drug desferal cleave DNA, in contrast to the corresponding Fe(II) complex which does not bring about DNA scission. Hydroxy radical scavengers inhibit the cleavage reaction. © 1992.

引用

页码：588 / 592

页数：5

共 29 条

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