DIRECT OBSERVATION OF A TERNARY COMPLEX BETWEEN THE DIMERIC ENZYME HIV-1 PROTEASE AND A SUBSTRATE-BASED INHIBITOR

被引:151
作者
BACA, M [1 ]
KENT, SBH [1 ]
机构
[1] SCRIPPS RES INST, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA
关键词
D O I
10.1021/ja00036a066
中图分类号
O6 [化学];
学科分类号
0703 ;
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引用
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页码:3992 / 3993
页数:2
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共 20 条
  • [1] SOLID-PHASE SYNTHESIS OF HYDROXYETHYLAMINE PEPTIDE-BOND ISOSTERES - SYNTHESIS OF THE POTENT-HIV-1 PROTEASE INHIBITOR JG365
    ALEWOOD, PF
    BRINKWORTH, RI
    DANCER, RJ
    GARNHAM, B
    JONES, A
    KENT, SBH
    [J]. TETRAHEDRON LETTERS, 1992, 33 (07) : 977 - 980
  • [2] ION SPRAY INTERFACE FOR COMBINED LIQUID CHROMATOGRAPHY/ATMOSPHERIC PRESSURE IONIZATION MASS-SPECTROMETRY
    BRUINS, AP
    COVEY, TR
    HENION, JD
    [J]. ANALYTICAL CHEMISTRY, 1987, 59 (22) : 2642 - 2646
  • [3] PROBING CONFORMATIONAL-CHANGES IN PROTEINS BY MASS-SPECTROMETRY
    CHOWDHURY, SK
    KATTA, V
    CHAIT, BT
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (24) : 9012 - 9013
  • [4] Covey T R, 1988, Rapid Commun Mass Spectrom, V2, P249, DOI 10.1002/rcm.1290021111
  • [5] DARKE PL, 1989, J BIOL CHEM, V264, P2307
  • [6] HUMAN IMMUNODEFICIENCY VIRUS PROTEASE EXPRESSED IN ESCHERICHIA-COLI EXHIBITS AUTOPROCESSING AND SPECIFIC MATURATION OF THE GAG PRECURSOR
    DEBOUCK, C
    GORNIAK, JG
    STRICKLER, JE
    MEEK, TD
    METCALF, BW
    ROSENBERG, M
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (24) : 8903 - 8906
  • [7] DESIGN, ACTIVITY, AND 2.8 A CRYSTAL-STRUCTURE OF A C2 SYMMETRICAL INHIBITOR COMPLEXED TO HIV-1 PROTEASE
    ERICKSON, J
    NEIDHART, DJ
    VANDRIE, J
    KEMPF, DJ
    WANG, XC
    NORBECK, DW
    PLATTNER, JJ
    RITTENHOUSE, JW
    TURON, M
    WIDEBURG, N
    KOHLBRENNER, WE
    SIMMER, R
    HELFRICH, R
    PAUL, DA
    KNIGGE, M
    [J]. SCIENCE, 1990, 249 (4968) : 527 - 533
  • [8] ELECTROSPRAY IONIZATION FOR MASS-SPECTROMETRY OF LARGE BIOMOLECULES
    FENN, JB
    MANN, M
    MENG, CK
    WONG, SF
    WHITEHOUSE, CM
    [J]. SCIENCE, 1989, 246 (4926) : 64 - 71
  • [9] FITZGERALD PMD, 1990, J BIOL CHEM, V265, P14209
  • [10] OBSERVATION OF NONCOVALENT ENZYME SUBSTRATE AND ENZYME PRODUCT COMPLEXES BY ION-SPRAY MASS-SPECTROMETRY
    GANEM, B
    LI, YT
    HENION, JD
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (20) : 7818 - 7819