STRUCTURE-ACTIVITY-RELATIONSHIPS IN KAPPA-OPIOID ANALGESICS - PIPERIDINES CONTAINING NOVEL OXO-ACYLATING MOIETIES

被引：3

作者：

DONDIO, G

COLLE, R

GIARDINA, G

PETRONE, G

SBACCHI, M

VECCHIETTI, V

CLARKE, GD

机构：

[1] Zambeletti Research Laboratories (SmithKline Beecham Italy), Milan, Via Zambeletti

来源：

PHARMACOLOGICAL RESEARCH | 1992年 / 25卷

关键词：

AMINOMETHYLPIPERIDINES; ANALGESIC ACTIVITY; KAPPA-BINDING AFFINITY;

D O I：

10.1016/1043-6618(92)90379-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：234 / 235

页数：2

共 5 条

[1]

SBACCHI M, 1990, NEW LEADS OPIOID RES, P211

[2] (2S)-1-(ARYLACETYL)-2-(AMINOMETHYL)PIPERIDINE DERIVATIVES - NOVEL, HIGHLY SELECTIVE KAPPA-OPIOID ANALGESICS [J].

VECCHIETTI, V ;

GIORDANI, A ;

GIARDINA, G ;

COLLE, R ;

CLARKE, GD .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) :397-403

[3] (1S)-1-(AMINOMETHYL)-2-(ARYLACETYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND HETEROCYCLE-CONDENSED TETRAHYDROPYRIDINE DERIVATIVES - MEMBERS OF A NOVEL CLASS OF VERY POTENT KAPPA-OPIOID ANALGESICS [J].

VECCHIETTI, V ;

CLARKE, GD ;

COLLE, R ;

GIARDINA, G ;

PETRONE, G ;

SBACCHI, M .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (08) :2624-2633

[4]

VECCHIETTI V, 1991, Patent No. 17116

[5]

VECCHIETTI V, 1989, Patent No. 333315

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