SIMPLE DIRECT-INJECTION HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD TO DETERMINE QUINIDINE IN PLASMA

被引：4

作者：

HUANG, JL ^{[1
]}

MORGAN, DJ ^{[1
]}

机构：

[1] MONASH UNIV,VICTORIAN COLL PHARM,381 ROYAL PARADE,PARKVILLE,VIC 3052,AUSTRALIA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 620卷 / 02期

关键词：

D O I：

10.1016/0378-4347(93)80017-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

High-performance liquid chromatographic methods that use direct injection of plasma include column-switching procedures, modified mobile phases and small-pore modified stationary phases. By using a large-pore (300 angstrom) Selectosil C18 column, developed for the analysis of macromolecules, we have shown that quinidine in plasma and protein solutions can be assayed accurately and rapidly by directly injecting 2 mul plasma or protein solution onto the column. Column life is not reduced, and the limit of quantitation is 0.01 muM.

引用

页码：278 / 280

页数：3

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