TREATMENT OF EXPERIMENTAL VISCERAL LEISHMANIASIS IN A T-CELL-DEFICIENT HOST - RESPONSE TO AMPHOTERICIN-B AND PENTAMIDINE

被引：42

作者：

MURRAY, HW ^{[1
]}

HARIPRASHAD, J ^{[1
]}

FICHTL, RE ^{[1
]}

机构：

[1] NEW YORK HOSP,DEPT PHARM,NEW YORK,NY 10021

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 07期

关键词：

D O I：

10.1128/AAC.37.7.1504

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In experimental visceral leishmaniasis, euthymic but not athymic (nude) BALB/c mice respond to conventional treatment with pentavalent antimony, indicating that the in vivo efficacy of antimony is T cell dependent. This finding correlates with frequent antimony treatment failures for T-cell-deficient patients with visceral leishmaniasis. To determine whether the in vivo efficacies of alternative antileishmanial agents also require T cells, Leishmania donovani-infected euthymic and nude BALB/c mice were treated with pentamidine or amphotericin B. Pentamidine induced leishmanistatic activity in euthymic mice but had little effect in nude mice. In contrast, amphotericin B exerted potent leishmanicidal activities in both euthymic and nude animals. These results suggest that amphotericin B may be of particular use for T-cell-deficient patients with visceral leishmaniasis.

引用

页码：1504 / 1505

页数：2

共 13 条

[1] VISCERAL LEISHMANIASIS - ANOTHER HIV-ASSOCIATED OPPORTUNISTIC INFECTION - REPORT OF 8 CASES AND REVIEW OF THE LITERATURE [J].