MAKALUVAMINE-G, A CYTOTOXIC PIGMENT FROM AN INDONESIAN SPONGE HISTODERMELLA SP

被引：86

作者：

CARNEY, JR

SCHEUER, PJ

KELLYBORGES, M

机构：

[1] UNIV HAWAII MANOA, DEPT CHEM, 2545 MALL, HONOLULU, HI 96822 USA

[2] HARBOR BRANCH OCEANOG INST INC, FT PIERCE, FL 34948 USA

来源：

TETRAHEDRON | 1993年 / 49卷 / 38期

关键词：

D O I：

10.1016/S0040-4020(01)96256-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cytotoxic pigment, makaluvamine G (5), biogenetically derivable from tryptamine and tyramine and structurally related to the discorhabdins, was isolated from a sponge of the genus Histodermella collected in Indonesia. The compound displays significant in vitro cytotoxicity to several tumor cell lines and is a moderate inhibitor of topoisomerase-I, DNA, RNA, and protein synthesis.

引用

页码：8483 / 8486

页数：4

共 14 条

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