AGGRAVATION OF PARKINSONIAN TREMOR BY CISAPRIDE

被引：21

作者：

SEMPERE, AP

DUARTE, J

CABEZAS, C

CLAVERIA, LE

CORIA, F

机构：

[1] Department of Neurology, Segovia General Hospital, Segovia

来源：

CLINICAL NEUROPHARMACOLOGY | 1995年 / 18卷 / 01期

关键词：

D O I：

10.1097/00002826-199502000-00010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cisapride, a substituted piperidinyl benzamide that is chemically related to metoclopramide, is a prokinetic agent that facilitates motility of the gastrointestinal tract (1). The mechanism by which cisapride exerts its actions is not clear. It enhances acetylcholine release in the myenteric plexus of the gut, and evidence exists that it has an agonistic action on a serotonin receptor, probably the 5-HT4 receptor (2). The drug is well tolerated, and no central nervous system side effects have been reported. We describe two patients with parkinsonism who experienced aggravation of tremor while on therapy with cisapride.

引用

页码：76 / 78

页数：3

共 8 条

[1] MONOAMINES IN HUMAN NEOSTRIATUM - TOPOGRAPHIC DISTRIBUTION IN NORMALS AND IN PARKINSONS DISEASE AND THEIR ROLE IN AKINESIA, RIGIDITY, CHOREA, AND TREMOR [J].