ROLE OF THROMBOXANE IN MEDIATING THE INTRARENAL VASOCONSTRICTION INDUCED BY UNMODIFIED STROMA FREE HEMOGLOBIN IN THE ISOLATED PERFUSED RAT-KIDNEY

被引：218

作者：

LIEBERTHAL, W

LARAIA, J

VALERI, CR

机构：

[1] BOSTON UNIV HOSP,MED CTR,DEPT MED,BOSTON,MA 02218

[2] BOSTON UNIV,MED CTR,NAVAL BLOOD RES LAB,BOSTON,MA 02118

来源：

BIOMATERIALS ARTIFICIAL CELLS AND IMMOBILIZATION BIOTECHNOLOGY | 1992年 / 20卷 / 2-4期

关键词：

D O I：

10.3109/10731199209119698

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Unmodified stroma free hemoglobin (SFH) increased renal vascular resistance (RVR) from 4.0+/-0.2 to 6.9+/-0.9 mmHg/ml/min in control isolated kidneys. In kidneys obtained from rats pretreated with the thromboxane synthetase inhibitor OKY-046 RVR increased from 3.9+/-0.3 to 4.8+/-0.4 mmHg/ml/min. The percent increase in RVR was greater in response to SFH in control kidneys (67+/-14%) than in OKY-046 treated kidneys (23+/-7%)(p<0.05). SFH resulted in a fall in glomerular filtration rate (GFR) from 0.75+/-0.09 to 0.21+/-0.04 ml/min in control kidneys while in kidneys from OKY-0.46 treated rats GFR fell from 0.65+/-0.04 to 0.54+/-0.06 ml/min. The percent fall in GFR was greater in vehicle treated kidneys (69+/-8%) as opposed to OKY-046 treated kidneys (19+/-7%)(p<0.05). The rate of urinary thromboxane excretion measured before the addition of SFH to the perfusate was 52 pg/min in the control group and 7 pg/min in the OKY-046 treated group(p<0.05).

引用

页码：663 / 667

页数：5