BONE MORPHOGENETIC PROTEIN-2 AND PROTEIN-4 ARE INVOLVED IN THE RETINOIC ACID-INDUCED DIFFERENTIATION OF EMBRYONAL CARCINOMA-CELLS

被引:75
作者
ROGERS, MB
ROSEN, V
WOZNEY, JM
GUDAS, LJ
机构
[1] CORNELL UNIV,MED CTR,COLL MED,DEPT PHARMACOL,NEW YORK,NY 10021
[2] GENET INST,CAMBRIDGE,MA 02140
关键词
D O I
10.1091/mbc.3.2.189
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Bone morphogenetic proteins-2 and -4 (BMPs-2 and -4) are transforming growth factor-beta-related proteins that can induce bone formation in vivo. We observed that the level of endogenous BMP-2 mRNA increased an average of 11-fold on differentiation of F9 embryonal carcinoma cells into parietal endoderm after treatment with retinoic acid (RA) and cAMP, whereas the message for the closely related BMP-4 decreased 12-fold after this treatment. Therefore, the effects of exogenous recombinant BMP-2 protein on the RA-induced differentiation of F9 embryonal carcinoma cells were investigated. BMP-2 addition altered the growth and morphology of RA-treated but not untreated cells. Moreover, the abundance of several messages was affected by exogenous BMP-2 treatment. Notably, the BMP-2 and -4 messages themselves were reduced by the addition of exogenous BMP-2. The observations suggest that RA, which is known to affect bone morphogenesis, may regulate the osteoinductive proteins, BMP-2 and -4. Furthermore, BMP-2 and -4 may be involved in preimplantation embryogenesis.
引用
收藏
页码:189 / 196
页数:8
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