DETECTION OF HTLV-I ANTIGEN IN PERIPHERAL AND CORD BLOOD-LYMPHOCYTES FROM CARRIER MOTHERS

被引：27

作者：

SATOW, YI

HASHIDO, M

ISHIKAWA, KI

HONDA, H

MIZUNO, M

KAWANA, T

HAYAMI, M

机构：

[1] UNIV TOKYO,DEPT OBSTET & GYNAECOL,MEJIRODAI,JAPAN

[2] MITSUI MEM HOSP,DEPT OBSTET & GYNAECOL,TOKYO 101,JAPAN

[3] UNIV TOKYO,DEPT OBSTET & GYNAECOL,TOKYO 113,JAPAN

[4] UNIV TOKYO,INST MED SCI,DEPT ANIM PATHOL,SHIROGANEDAI,JAPAN

[5] KYOTO UNIV,INST VIRUS RES,IMMUNODEFICIENCY VIRUS RES CTR,KYOTO 606,JAPAN

来源：

LANCET | 1991年 / 338卷 / 8772期

关键词：

D O I：

10.1016/0140-6736(91)91775-P

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vertical transmission of human T-cell lymphotropic virus type-I (HTLV-I) from an antibody-positive carrier mother to her infant has been reported, but it is not clear when and by what route such transmission occurs. Peripheral blood and cord blood lymphocytes from 40 antibody-positive carrier mothers were cultured for 2 months and HTLV-I antigen was sought by indirect immunofluorescence. Viral antigen was detected in 28 (70%) samples of peripheral blood lymphocytes and in 2 of cord blood lymphocytes, both from mothers positive for antigen in peripheral blood. From these data it is estimated that transplacental infection occurs at a rate of about 7%.

引用

页码：915 / 916

页数：2

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