HIGH-RESOLUTION ACCURATE MASS MEASUREMENT OF PRODUCT IONS FORMED IN AN ELECTROSPRAY SOURCE ON A SECTOR INSTRUMENT

被引:17
作者
STARRETT, AM [1 ]
DIDONATO, GC [1 ]
机构
[1] BRISTOL MYERS SQUIBB CO, PHARMACEUT RES INST, DEPT ANALYT RES & DEV, PRINCETON, NJ 08543 USA
关键词
D O I
10.1002/rcm.1290070104
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The high resolution accurate mass measurement of product ions formed by collisionally activated dissociation in an electrospray source has been achieved using a reversed-geometry double-focusing mass spectrometer and accelerating voltage scans. Accurate mass measurements of productions from angiotensin I, angiotensin II, leucine enkephalinamide, substance P (1-9) and a synthetic compound of pharmaceutical interest were obtained with an average error of <5 ppm.
引用
收藏
页码:12 / 15
页数:4
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