PRODUCTION OF S-(+)-IBUPROFEN WITH HIGH OPTICAL PURITY FROM A NITRILE COMPOUND BY CELLS IMMOBILIZED ON CELLULOSE POROUS BEADS

被引:15
作者
TAKAGI, M [1 ]
SHIROKAZE, JI [1 ]
OISHI, K [1 ]
OTSUBO, K [1 ]
YAMAMOTO, K [1 ]
YOSHIDA, N [1 ]
FUJIMATSU, I [1 ]
机构
[1] ASAHI CHEM IND CO LTD,DEPT CELLULOSE FIBERS DEV,MIYAZAKI 882,JAPAN
来源
JOURNAL OF FERMENTATION AND BIOENGINEERING | 1994年 / 78卷 / 02期
关键词
D O I
10.1016/0922-338X(94)90264-X
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The production of S-(+)-ibuprofen (S-IP) from a nitrile compound by immobilized cells was investigated. Cells immobilized within both kappa-carrageenan and Ca-alginate showed a lower reaction conversion and gave a product of lower optical purity than free, intact cells. However the reaction of cells immobilized in cellulose porous beads (CPBs) with pore sizes of 10-30 mu m and an average diameter of 200 mu m resulted in a yield and optical purity as high as those given by intact cells. Even when the CPBs were used repeatedly up to 12 times, an S-IP optical purity of more than 99% was maintained, but the reaction conversion decreased from 48% to 32%.
引用
收藏
页码:191 / 193
页数:3
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