EFFECT OF THYROID-HORMONE ON HEPATIC CHOLESTEROL 7-ALPHA-HYDROXYLASE, LDL RECEPTOR, HMG-COA REDUCTASE, FARNESYL PYROPHOSPHATE SYNTHETASE AND APOLIPOPROTEIN-A-I MESSENGER-RNA LEVELS IN HYPOPHYSECTOMIZED RATS

被引：142

作者：

NESS, GC ^{[1
]}

PENDLETON, LC ^{[1
]}

LI, YC ^{[1
]}

CHIANG, JYL ^{[1
]}

机构：

[1] NORTHEASTERN OHIO UNIV,COLL MED,DEPT BIOCHEM & MOLEC PATHOL,ROOTSTOWN,OH 44272

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)91568-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of thyroid hormone on cholesterol 7α hydroxylase, LDL receptor, HMG-CoA reductase, apo A-I and farnesyl pyrophosphate synthetase hepatic mRNA levels were investigated in hypophysectomized rats. Of these mRNAs cholesterol 7α hydroxylase responded the most rapidly and required the lowest dose of T3. Maximal mRNA levels were reached one hr after T3 administration and required 10 μg/100g of body weight. These results suggest that the hypocholesterolemic effect of thyroid hormone may be mediated by a primary effect on cholesterol 7α hydroxylase gene expression. © 1990.

引用

页码：1150 / 1156

页数：7

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