SERUM HEPATITIS-B VIRUS-DNA IN HEALTHY HBSAG-NEGATIVE CHINESE ADULTS EVALUATED BY POLYMERASE CHAIN-REACTION

被引：64

作者：

SHIH, LN ^{[1
]}

SHEU, JC ^{[1
]}

WANG, JT ^{[1
]}

HUANG, GT ^{[1
]}

YANG, PM ^{[1
]}

LEE, HS ^{[1
]}

SUNG, JL ^{[1
]}

WANG, TH ^{[1
]}

CHEN, DS ^{[1
]}

机构：

[1] NATL TAIWAN UNIV HOSP,COLL MED,GRAD INST CLIN MED,DEPT INTERNAL MED,1 CHANG TE ST,TAIPEI 10016,TAIWAN

来源：

JOURNAL OF MEDICAL VIROLOGY | 1990年 / 32卷 / 04期

关键词：

SEROLOGICAL MARKERS; DONOR SCREENING METHODS; CHRONIC LIVER DISEASE;

D O I：

10.1002/jmv.1890320412

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Serum hepatitis B virus (HBV) DNA was assayed using polymerase chain reaction, in 107 HBsAg-negative normal Chinese subjects. The results showed that eight subjects (7.5%) had HBV DNA. In the subgroup with antibody to hepatitis B surface antigen (anti-HBs) and to hepatitis B core antigen (anti-HBc), 7.3% (5/68) were positive for HBV DNA; HBV DNA was not detected in six individuals with anti-HBs only and in nine with anti-HBc only. In four persons with anti-HBc and anti-HBe, one had HBV DNA. In 20 subjects negative for all hepatitis B serological markers, two (10%) were found to have HBV DNA. This study indicates that serological markers are not adequate to rule out HBV infection, and it further implies that present blood donor screening methods may need improving.

引用

页码：257 / 260

页数：4

共 18 条

[1] STATE OF HEPATITIS-B VIRUS-DNA IN HEPATOCYTES OF PATIENTS WITH HEPATITIS-B SURFACE ANTIGEN-POSITIVE AND ANTIGEN-NEGATIVE LIVER-DISEASES [J].