CONTACT SITES BETWEEN INNER AND OUTER MEMBRANES - STRUCTURE AND ROLE IN PROTEIN TRANSLOCATION INTO THE MITOCHONDRIA

被引：27

作者：

PFANNER, N

RASSOW, J

WIENHUES, U

HERGERSBERG, C

SOLLNER, T

BECKER, K

NEUPERT, W

机构：

[1] Institut für Physiologische Chemie, Universität München, München

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1018卷 / 2-3期

关键词：

Contact site; Mitochondrion; Protein import; Protein unfolding;

D O I：

10.1016/0005-2728(90)90257-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Contact sites between both mitochondrial membranes play a predominant role in the transport of nuclear-coded precursor proteins into mitochondria. The characterization of contact sites was greatly advanced by the reversible accumulation of precursor proteins in transit (translocation intermediates). It was found that the sites are saturable, apparently contain proteinaceous components and mediate extensive unfolding of the polypeptide chain in translocation. Some components of mitochondrial contact sites are currently being identified. © 1990.

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页码：239 / 242

页数：4

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