LEVEL OF CORTICOSTERONE REPLACEMENT DETERMINES BODY-WEIGHT GAIN IN ADRENALECTOMIZED RATS WITH VMH LESIONS

被引：8

作者：

KING, BM ^{[1
]}

ZANSLER, CA ^{[1
]}

TATFORD, AC ^{[1
]}

NEVILLE, KL ^{[1
]}

SAM, H ^{[1
]}

KASS, JM ^{[1
]}

DALLMAN, MF ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143

来源：

PHYSIOLOGY & BEHAVIOR | 1993年 / 54卷 / 06期

关键词：

VENTROMEDIAL HYPOTHALAMUS; ADRENALECTOMY; CORTICOSTERONE; BODY WEIGHT; FOOD INTAKE; ACTH; INSULIN;

D O I：

10.1016/0031-9384(93)90346-H

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Adrenalectomized female rats with lesions of the ventromedial hypothalamus or sham lesions were given SC implants of wax pellets or a fused mixture of corticosterone-cholesterol (40, 75, or 130% by weight). In animals with sham lesions, high dosages of corticosterone proved to be catabolic (r = -0.61 between plasma corticosterone and weight change). In marked contrast, animals with VMH lesions displayed substantial weight gains at all circulating levels of corticosterone, with a significant positive correlation (r = +0.48) between these two variables. It is concluded that: a) damage to the basomedial hypothalamus alters an organism's response to corticosterone at both ends of the dose-response curve, and b) both Type I and Type II corticosterone receptors in the brain play a role in hypothalamic obesity.

引用

页码：1187 / 1190

页数：4

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