CURCACYCLINE-A - A NOVEL CYCLIC OCTAPEPTIDE ISOLATED FROM THE LATEX OF JATROPHA-CURCAS L

被引：73

作者：

VANDENBERG, AJJ

HORSTEN, SFAJ

KETTENESVANDENBOSCH, JJ

KROES, BH

BEUKELMAN, CJ

LEEFLANG, BR

LABADIE, RP

机构：

[1] UNIV UTRECHT, FAC PHARM, DEPT PHARMACEUT ANAL, 3508 TB UTRECHT, NETHERLANDS

[2] UNIV UTRECHT, FAC CHEM, BIJVOET CTR, DEPT NMR SPECT, 3508 TB UTRECHT, NETHERLANDS

来源：

FEBS LETTERS | 1995年 / 358卷 / 03期

关键词：

JATROPHA CARCAS; EUPHORBIACEAE; CURCACYCLINE A; CYCLIC PEPTIDE;

D O I：

10.1016/0014-5793(94)01405-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From the latex of Jatropha curcas L. (Euphorbiaceae) a novel cyclic octapeptide was isolated, which we named curcacycline A. The compound was found to contain one threonine, one valine, two glycine, and four leucine residues. By two-dimensional H-1-NMR spectroscopy (HOHAHA and ROESY), its sequence was determined to be Gly(1)-Leu(2)-Leu(3)-Gly(4)-Thr(5)-Val(6)-Leu(7)-Leu(8)-Gly(1). Curcacycline A displays a moderate inhibition of (i) classical pathway activity of human complement and (ii) proliferation of human T-cells.

引用

页码：215 / 218

页数：4

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