THE ROLE OF THE BETA-SUBUNIT OF INITIATION FACTOR-EIF-2 IN INITIATION COMPLEX-FORMATION

被引：29

作者：

FLYNN, A

OLDFIELD, S

PROUD, CG

机构：

[1] Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, University Walk

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1174卷 / 01期

关键词：

PROTEIN SYNTHESIS; INITIATION FACTOR; GUANINE NUCLEOTIDE;

D O I：

10.1016/0167-4781(93)90105-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The functional properties of preparations of protein synthesis initiation factor eIF-2 which lack the beta-subunit (as confirmed immunologically) were compared with those of the heterotrimeric factor. The former can bind guanine nucleotides but not initiator tRNA, and also exhibits a substantially reduced rate of initiation factor eIF-2B-mediated GDP/GTP-exchange.

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页码：117 / 121

页数：5

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