EFFECT OF ISOVOLEMIC HEMODILUTION WITH DEXTRAN AND ALBUMIN ON THROMBUS FORMATION IN ARTIFICIAL VESSEL GRAFTS INSERTED INTO THE ABDOMINAL-AORTA OF THE RABBIT

被引：18

作者：

FROSTARNER, L

BERGQVIST, D

机构：

[1] Departments of Plastic and Reconstructive Surgery, Malmö General Hospital, Malmö

[2] Department of Experimental Research, Malmö General Hospital, Malmö

[3] Department of Surgery, Academic Hospital Uppsala, Uppsala

来源：

MICROSURGERY | 1995年 / 16卷 / 05期

关键词：

D O I：

10.1002/micr.1920160513

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The effects of isovolemic hemodilution with dextran-70 and albumin on thrombus formation in artificial arterial grafts were investigated, A polytetrafluoroethylene graft (PTFE, length 13 mm, inner diameter 3 mm) was inserted into the abdominal aorta of rabbits. Three groups of animals were studied; 1) animals receiving isovolemic hemodilution with dextran-70 (10 ml/kg body weight), 2) animals receiving isovolemic hemodilution with albumin (10 ml/kg body weight), and 3) nonhemodiluted controls. The blood flow increased by about 70% and 60% after the hemodilution with dextran and albumin, respectively, and remained high in the hemodiluted animals, after insertion of the graft, After 2 days the vessel graft was removed and weighed, The thrombus mass was separately weighed. The results suggest that isovolemic hemodilution with both albumin and dextran is associated with a marked increase in blood flow in the rabbit. Hemodilution with dextran also reduced the amount of thrombus formation on the inner wall of the graft. (C) 1995 Wiley-Liss, Inc.

引用

页码：357 / 361

页数：5

共 14 条

[1]

Acland R, Thrombus formation in microvascular surgery, Surgery, 73, pp. 766-773, (1973)

[2]

Lidman DH, Faibisoff B, Daniel RK, Expanded polytetrafluoroethylene as a microvascular graft: an experimental study, J Microsurg, 1, pp. 447-456, (1980)

[3]

Veith FJ, Gupta S, Daly V, Management of early and late thrombosis of expanded PTFE femoropopliteal bypass grafts, Surgery, 87, pp. 581-587, (1980)

[4]

Messmer K, Sunder-Plassmann L, Kloevekorn WP, Holper K, Circulatory significance of hemodilution: Rheological changes and limitations, Adv Microcirc, 4, pp. 1-77, (1972)

[5]

Goulian D, The use of bromphenol blue in the assay of rheomacrodex effects in flap viability, Plast Reconstr Surg, 39, pp. 227-233, (1967)

[6]

Barker JH, Menger M, Sack FU, Messmer K, The effect of normo‐volemic hemodilution on skin flap survival, Int J Microcirc, 6, (1987)

[7]

Wieslander JB, Dougan P, Stjernquist U, Aberg M, Bergentz SE, The influence of dextran and saline solution upon platelet behavior after microarterial anastomosis, Surg Gynecol Obstet, 163, pp. 256-262, (1986)

[8]

Mahir MS, Hynd JW, Flute PT, Dormandy JA, Effect of defibrino‐genation on the early patency rate of experimental small calibre arterial grafts, Br J Surg, 74, pp. 508-510, (1987)

[9]

Frost-Arner L, Aberg M, Bruckner UB, Wieslander JB, Messmer K, Effects of normovolemic hemodilution on blood flow in the rabbit ear, Microsurgery, 11, pp. 19-24, (1990)

[10]

Frost-Arner L, Bergqvist D, (1993)

← 1 2 →