BREAST-CANCER INCIDENCE BEFORE AGE-55 IN RELATION TO PARITY AND AGE AT FIRST AND LAST BIRTHS - A PROSPECTIVE-STUDY OF ONE MILLION NORWEGIAN WOMEN

被引：48

作者：

ALBREKTSEN, G

HEUCH, I

TRETLI, S

KVALE, G

机构：

[1] Department of Epidemiology, University of Bergen, Bergen

[2] Department of Mathematics, University of Bergen, Bergen

[3] The Cancer Registry of Norway, Institute of Epidemiological Cancer Research, Oslo

来源：

EPIDEMIOLOGY | 1994年 / 5卷 / 06期

关键词：

COHORT STUDY; BREAST CANCER; YOUNG WOMEN; PARITY; AGE AT FIRST BIRTH; AGE AT LAST BIRTH;

D O I：

10.1097/00001648-199411000-00008

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We examined the relation between breast cancer, parity, and age at first and last births in a large national cohort of young women in Norway. We estimated relative incidence rates by Poisson regression analyses of person-years at risk with parity and age at last (most recent) birth as time-dependent variables. A total of 1,071,795 women were included in follow up, contributing a total of 16,643,883 person-years in the age range 20-54 years. Follow up rimes ranged from 1 month to 34.5 years. A rod of 4,302 women were diagnosed with breast cancer during follow-up. With adjustment for age at first: and last births, high parity was associated with an overall reduced risk of breast cancer (incidence rate ratio = 0.46 95% confidence interval = 0.36-0.59 for women with five or more children us uniparous women). Among women age 20-29 years, however, the results suggested an increase in risk with increasing parity (incidence rare ratio = 1.25; 95% confidence interval = 0.64-2.45 for women with three children us uniparous women). The protective effect of high parity was particularly strong among women with first birth before the age of 20 years and rather weak among those with first birth at age 30 years or more. Low ages at: first and last births were both associated with reduced breast: cancer risk in analyses with adjustment for the other factor, with the association with age at last birth being slightly stronger.

引用

页码：604 / 611

页数：8

共 32 条

[1] Adami H.-O., Adams G., Boyle P., Ewertz M., Lee N.C., Lund E., Miller A.B., Olsson H., Steel M., Trichopoulos D., Tulinius H., Breast-cancer etiology, Int J Cancer, 5, pp. 22-39, (1990)
[2] Kvale G., Reproductive factors in breast cancer epidemiology, Acta Oncol, 31, pp. 1-8, (1992)
[3] Bruzzi P., Negri E., La Vecchia C., Decarli A., Palli D., Parazzini F., Rosselli Del Turco M., Short term increase in risk of breast cancer after full term pregnancy, Br Med J, 297, pp. 1096-1098, (1988)
[4] Lubin J.H., Bums P.E., Blot W.J., Lees A.W., May C., Morris L.E., Fraumeni J.F., Risk factors for breast cancer in women in Northern Alberta, Canada, as related to age at diagnosis, J Natl Cancer Inst, 68, pp. 211-217, (1982)
[5] Miller A.B., Barclay T.H.C., Choi N.W., Grace M.G., Wall C., Plante M., Howe G.R., Cinader B., Davis F.G., A study of cancer, parity and age at first pregnancy, J Chron Dis, 33, pp. 595-605, (1980)
[6] Layde P.M., Webster L.A., Baughman A.L., Wingo P.A., Rubin G.L., Ory H.W., The Cancer and Steroid Hormone Study Group. The independent associations of parity, age at first full term pregnancy, and duration of breastfeeding with the risk of breast cancer, J Clin Epidemiol, 42, pp. 963-973, (1989)
[7] Pathak D.R., Speizer F.E., Willett W.C., Rosner B., Lipnick R.J., Parity and breast cancer risk: Possible effect on age at diagnosis, Int J Cancer, 37, pp. 21-25, (1986)
[8] Ewertz M., Duffy S.W., Adami H.-O., Kvale G., Lund E., Meirik O., Mellemgaard A., Soini I., Tulinius H., Age at first birth, parity, and risk of breast cancer: A meta-analysis of 8 studies from the Nordic countries, Int J Cancer, 46, pp. 597-603, (1990)
[9] Williams E.M.I., Jones L., Vessey M.P., McPherson K., Short term increase in risk of breast cancer associated with full term pregnancy, Br Med J, 300, pp. 578-579, (1990)
[10] Leon D.A., A prospective study of the independent effects of parity and age at first birth on breast cancer incidence in England and Wales, Int J Cancer, 43, pp. 986-991, (1989)

← 1 2 3 4 →