PH POSITIVE ACUTE LYMPHOBLASTIC-LEUKEMIA IN ADULTS - MOLECULAR AND CLINICAL-STUDIES

被引：20

作者：

SPECCHIA, G ^{[1
]}

MININNI, D ^{[1
]}

GUERRASIO, A ^{[1
]}

PALUMBO, G ^{[1
]}

PASTORE, D ^{[1
]}

LISO, V ^{[1
]}

机构：

[1] UNIV BARI,DEPT HEMATOL,BARI,ITALY

来源：

LEUKEMIA & LYMPHOMA | 1995年 / 18卷

关键词：

PH+; ALL; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULTS; MOLECULAR GENETICS; CLINICAL STUDIES;

D O I：

10.3109/10428199509075301

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fifty-six patients with ALL were investigated for bcr involvement by PCR. Breakpoints were found in 15 patients (26.8%). There were no differences in clinical and hematologic features or the percentages of complete response (CR) between the Ph+ and Ph- cases. The duration of CR was 6 and 8 months, respectively. In 7/9 Ph1 relapsed ALL we observed increased expression of myeloid markers and 2/9 showed a switch of cytotype (Ly --> My). In none of the 13 Ph- relapsed ALL patients did we observe these findings. 7/15 of Ph+ cases expressed P190 and mRNA ela2 and 8/15 patients showed P210, with mRNA b3a2 in 5 and b2a2 in 3, respectively. The percentage of CR was 57% in the P190+ and 87% in the P210+ group. Investigation of more Ph1+ ALL cases treated with a uniform protocol should be performed in the future in order to determine whether any such biological and clinical differences exist.

引用

页码：37 / &

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