DRUG RESIDUE FORMATION FROM RONIDAZOLE, A 5-NITROIMIDAZOLE .5. CYSTEINE ADDUCTS FORMED UPON REDUCTION OF RONIDAZOLE BY DITHIONITE OR RAT-LIVER ENZYMES IN THE PRESENCE OF CYSTEINE

被引：31

作者：

WISLOCK, PG ^{[1
]}

BAGAN, ES ^{[1
]}

VANDENHEUVEL, WJA ^{[1
]}

WALKER, RW ^{[1
]}

ALVARO, RF ^{[1
]}

ARISON, BH ^{[1
]}

LU, AYH ^{[1
]}

WOLF, FJ ^{[1
]}

机构：

[1] MERCK SHARP & DOHME RES LABS, DEPT BIOPHYS, RAHWAY, NJ 07065 USA

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1984年 / 49卷 / 1-2期

关键词：

D O I：

10.1016/0009-2797(84)90049-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：13 / 25

页数：13

共 28 条

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[3] RADIOSENSITIZATION OF HYPOXIC TUMOR-CELLS BY DEPLETION OF INTRACELLULAR GLUTATHIONE
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YU, NY
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[4] EDWARDS DI, 1981, PROGR MED CHEM, V18, P87, DOI 10.1016/S0079-6468(08)70317-5
[5] REACTIONS OF NITROIMIDAZOLES - NUCLEOPHILIC-SUBSTITUTION OF THE NITRO-GROUP
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[6] MODE OF ACTION OF METRONIDAZOLE IN TRICHOMONAS-VAGINALIS AND OTHER MICROORGANISMS
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ORMEROD, WE
[J]. BIOCHEMICAL PHARMACOLOGY, 1974, 23 (09) : 1421 - 1429
[7] INTERACTION OF REDUCED METRONIDAZOLE WITH DNA
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[J]. BIOCHEMICAL PHARMACOLOGY, 1978, 27 (17) : 2089 - 2093
[8] ASCORBATE ANION POTENTIATES CYTOTOXICITY OF NITRO-AROMATIC COMPOUNDS UNDER HYPOXIC AND ANOXIC CONDITIONS
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HOWELL, RL
BIAGLOW, JE
[J]. BRITISH JOURNAL OF CANCER, 1979, 39 (03) : 321 - 329
[9] COMPARATIVE MISONIDAZOLE METABOLISM IN ANAEROBIC-BACTERIA AND HYPOXIC CHINESE-HAMSTER LUNG FIBROBLAST (V-79-473) CELLS
KOCH, RL
ROSE, C
RICH, TA
GOLDMAN, P
[J]. BIOCHEMICAL PHARMACOLOGY, 1982, 31 (03) : 411 - 414
[10] THE MUTAGENICITY OF NITROAROMATIC DRUGS - EFFECT OF METRONIDAZOLE AFTER INCUBATION IN HYPOXIA INVITRO
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HORVAT, D
[J]. MUTATION RESEARCH, 1980, 78 (02): : 201 - 207

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