EXTREMELY MILD AND SELECTIVE METHOD FOR HYDROLYSIS OF TOSYL ESTERS BY PHOTO-SENSITIZED SINGLE ELECTRON-TRANSFER REACTIONS

被引：8

作者：

NISHIDA, A

HAMADA, T

YONEMITSU, O

机构：

[1] Faculty Of Pharmaceutical Sciences, Hokkaido University

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 11期

关键词：

electron-rich aromatic compound; hydrolysis; nucleoside; photo-sensitization; single electron; sugar; tosyl ester; transfer; UV irradiation;

D O I：

10.1248/cpb.38.2977

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Tosyl esters were hydrolyzed by irradiation with ultraviolet light (>330nm) under photo-sensitized conditions. 1,5-Dimethoxynaphthalene and (4,8-dimethoxynaphthyl)propionic acid were effective for the transformation in aqueous acetonitrile in the presence of hydrazine. The reaction was successfully applied to the hydrolysis of tosylates of sugars and nucleosides. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：2977 / 2980

页数：4

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