THE CONCENTRATION OF GLUCOSE IN THE CULTURE-MEDIUM DETERMINES THE EFFECT OF SURAMIN ON THE GROWTH AND DIFFERENTIATION OF THE HUMAN COLONIC ADENOCARCINOMA CELL CLONE HT29-D4

被引：9

作者：

RABENANDRASANA, C

BAGHDIGUIAN, S

ROCCABIANCA, M

BRUNET, M

MARVALDI, J

FANTINI, J

机构：

[1] UNIV AIX MARSEILLE 1,CNRS,URA 202,3 PL VICTOR HUGO,F-13331 MARSEILLE 3,FRANCE

[2] UNIV AIX MARSEILLE 1,BIOL ANIM LAB,F-13331 MARSEILLE 3,FRANCE

来源：

CANCER LETTERS | 1990年 / 53卷 / 2-3期

关键词：

colon cancer cells; differentiation; glucose; HT29-D4; suramin;

D O I：

10.1016/0304-3835(90)90202-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Suramin, a drug currently used for advanced malignancy, induces the differentiation of the human colonic adenocarcinoma cell clone HT29-D4 and this process is correlated with a decreased glycolytic activity. We investigated the effects of suramin on HT29-D4 cells in the presence of various glucose concentrations. The main result of this study is that suramin has only an effect on HT29-D4 cell growth and differentiation when the concentration of glucose is above 10 mM. Therefore the efficiency of suramin as an anticancer drug may be greater on poorly differentiated tumoral cells with a high proliferative capacity. © 1990.

引用

页码：109 / 115

页数：7

共 15 条

[1] EFFICIENT REVERSION OF SIMIAN SARCOMA VIRUS-TRANSFORMATION AND INHIBITION OF GROWTH FACTOR-INDUCED MITOGENESIS BY SURAMIN [J].