LEUKOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 (LFA-1) IS A SIGNALING MOLECULE FOR CYTOSKELETAL CHANGES IN A HUMAN T-CELL LINE

被引：17

作者：

KELLEHER, D

MURPHY, A

CULLEN, D

机构：

[1] ST JAMES HOSP,DEPT IMMUNOL,DUBLIN 8,IRELAND

[2] ST JAMES HOSP,DEPT HISTOPATHOL,DUBLIN 8,IRELAND

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 10期

基金：

英国惠康基金;

关键词：

D O I：

10.1002/eji.1830201028

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The HuT 78/2 clone is a human T cell clone which has an activated phenotype. When this line was stimulated with immobilized antibody to LFA‐1, the majority of cells developed dendritic processes. These processes were demonstrated to contain cytoskeletal elements including microtubules and intermediate filaments. Phorbol myristate acetate synergized with and prolonged this effect. Thus, the LFA‐1 molecule may function as a signaling molecule for cytoskeletal reorganization in a human T cell clone. Copyright © 1990 Wiley‐VCH Verlag GmbH & Co. KGaA

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页码：2351 / 2354

页数：4

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