PYRROLES FROM ETHACRYNIC ACID

被引：3

作者：

GORLITZER, K

BOMEKE, M

机构：

[1] Institut Für Pharmazeutische Chemie, Technischen Universität Braunschweig, Braunschweig, 3300

来源：

ARCHIV DER PHARMAZIE | 1992年 / 325卷 / 01期

关键词：

D O I：

10.1002/ardp.19923250105

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 1,4-dicarbonyl and 1,4,7-tricarbonyl compounds 1 cyclize with ammonia or methylamine to yield the pyrroles 2. Dependent on the temp. the 1,4-diketone 1b reacts with hydrazine in ethanole to form the pyridazine 3 or the N-amino-pyrrole 4, respectively. Acetylation of 4 gives the stable amide 5. The N-hydroxy-pyrrole 6 is obtained by condensation of 1b with hydroxylamine.

引用

页码：13 / 15

页数：3

共 14 条

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