EFFECT OF EXOGENOUS SIALYLATION OF THE LIPOOLIGOSACCHARIDE OF NEISSERIA-GONORRHOEAE ON OPSONOPHAGOCYTOSIS

被引：60

作者：

KIM, JJ

ZHOU, DG

MANDRELL, RE

GRIFFISS, JM

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT LAB MED,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT PEDIAT,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

[4] VET ADM MED CTR,SAN FRANCISCO,CA 94121

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 10期

关键词：

D O I：

10.1128/IAI.60.10.4439-4442.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Serum-sensitive Neisseria gonorrhoeae strains become serum resistant when grown in the presence of a sialic acid precursor, cytidine monophospho-N-acetylneuraminic acid. We examined the abilities of human neutrophils to phagocytose sialylated and nonsialylated gonococci and observed a decrease in the complement-dependent phagocytosis of sialylated gonococci compared with that of nonsialylated gonococci (50.7 versus 25.9% survival at 30 min). This decrease in opsonophagocytosis after sialylation may contribute to the pathogenicity of gonococcal infections.

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收藏

页码：4439 / 4442

页数：4

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