GLUTATHIONE PEROXIDASE-LIKE ACTIVITY OF DIARYL TELLURIDES

被引：77

作者：

ANDERSSON, CM

HALLBERG, A

BRATTSAND, R

COTGREAVE, IA

ENGMAN, L

PERSSON, J

机构：

[1] ASTRA DRACO AB,DEPT PHARMACOL 1,S-22100 LUND,SWEDEN

[2] ASTRA DRACO AB,PRECLIN RES & DEV,S-22100 LUND,SWEDEN

[3] KAROLINSKA INST,DEPT TOXICOL,S-10401 STOCKHOLM 60,SWEDEN

[4] ROYAL INST TECHNOL,DEPT ORGAN CHEM,S-10044 STOCKHOLM 70,SWEDEN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80715-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

4,4'-Disubstituted diaryl tellurides showed glutathione peroxidase-like catalysis of the reduction of hydroperoxides by glutathione. The most potent compound, bis(4-aminophenyl) telluride, demonstrated 348%, 530%, 995% and 900% of the catalytic efficacy of Ebselen for the glutathione dependent reduction of H2O2, t-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide, respectively.

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页码：2553 / 2558

页数：6

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