STRATEGIES OF SYNTHESIS BASED ON CYCLOHEXADIENES .3. A NOVEL ROUTE TO MACROLIDE AROMATIC POLYKETIDES

被引：29

作者：

BIRCH, AJ ^{[1
]}

MANI, NS ^{[1
]}

RAO, GSRS ^{[1
]}

机构：

[1] INDIAN INST SCI,DEPT ORGAN CHEM,BANGALORE 560012,KARNATAKA,INDIA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1990年 / 05期

关键词：

D O I：

10.1039/p19900001423

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel route to macrolide aromatic polyketides, having an alkyl-β-resorcylate skeleton has been developed. A formal synthesis of (±)-curvularin (1), and (±)-lasiodiplodin (3) involving the preparation of the seco acid (31) and the acyclic precursor (34) using a one pot Alder-Rickert reaction from 1,3-dimethoxycyclohexa-1,3-diene (7) and the long-chain acetylenic dienophiles (10) and (11) is reported.

引用

页码：1423 / 1427

页数：5

共 17 条

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[6]

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[7]

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[8]

COREY EJ, 1979, TETRAHEDRON LETT, P399

[9] NAPHTHOQUINONE ANTIMALARIALS .29. 2-HYDROXY-3-(OMEGA-CYCLOHEXYLALKYL)-1,4-NAPHTHOQUINONES [J].

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