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DOPACHROME CONVERSION FACTOR FUNCTIONS AS AN ISOMERASE
被引:89
作者
:
PAWELEK, JM
论文数:
0
引用数:
0
h-index:
0
机构:
Department of Dermatology, Yale University School of Medicine New Haven
PAWELEK, JM
机构
:
[1]
Department of Dermatology, Yale University School of Medicine New Haven
来源
:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
|
1990年
/ 166卷
/ 03期
关键词
:
D O I
:
10.1016/0006-291X(90)91011-G
中图分类号
:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号
:
071010 ;
081704 ;
摘要
:
Dopachrome conversion factor is an enzymatic activity associated with the pigmentary system which catalyzes the conversion of dopachrome, an intermediate in melanin biosynthesis, to dihydroxyindole-2-carboxylic acid (DHICA). To date, the mechanism of action of DCF has been unknown because all previous assays have employed a dopachrome substrate contaminated with L-dopa. It has therefore not been possible to determine whether L-dopa acts as a hydrogen donor in the reaction or whether the formation of DHICA occurs through an isomerization of dopachrome. In this study it is shown that DCF catalyzes the conversion of dopachrome to DHICA equally well in the presence or absence of L-dopa. The DCF-mediated reaction thus appears to be an isomeric rearrangement of hydrogen ions from one portion of the dopachrome molecule to another. The results indicate that the name "dopachrome isomerase" appropriately describes the function of DCF. © 1990.
引用
收藏
页码:1328 / 1333
页数:6
相关论文
共 18 条
[1]
DECREASED DOPACHROME OXIDOREDUCTASE ACTIVITY IN YELLOW MICE
BARBER, JI
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
BARBER, JI
TOWNSEND, D
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
TOWNSEND, D
OLDS, DP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
OLDS, DP
KING, RA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
KING, RA
[J].
JOURNAL OF HEREDITY,
1985,
76
(01)
: 59
-
60
[2]
DOPACHROME OXIDOREDUCTASE - A NEW ENZYME IN THE PIGMENT PATHWAY
BARBER, JI
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DIV HUMAN & ORAL GENET,MINNEAPOLIS,MN 55455
BARBER, JI
TOWNSEND, D
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DIV HUMAN & ORAL GENET,MINNEAPOLIS,MN 55455
TOWNSEND, D
OLDS, DP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DIV HUMAN & ORAL GENET,MINNEAPOLIS,MN 55455
OLDS, DP
KING, RA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DIV HUMAN & ORAL GENET,MINNEAPOLIS,MN 55455
KING, RA
[J].
JOURNAL OF INVESTIGATIVE DERMATOLOGY,
1984,
83
(02)
: 145
-
149
[3]
MELANOGENIC REGULATORY FACTORS IN COATED VESICLES FROM MELANOMA-CELLS
CHAKRABORTY, AK
论文数:
0
引用数:
0
h-index:
0
机构:
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
CHAKRABORTY, AK
MISHIMA, Y
论文数:
0
引用数:
0
h-index:
0
机构:
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
MISHIMA, Y
INAZU, M
论文数:
0
引用数:
0
h-index:
0
机构:
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
INAZU, M
HATTA, S
论文数:
0
引用数:
0
h-index:
0
机构:
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
HATTA, S
ICHIHASHI, M
论文数:
0
引用数:
0
h-index:
0
机构:
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
ICHIHASHI, M
[J].
JOURNAL OF INVESTIGATIVE DERMATOLOGY,
1989,
93
(05)
: 616
-
620
[4]
HARLEYMASON J, 1950, NATURE, V106, P1036
[5]
NEW REGULATORS OF MELANOGENESIS ARE ASSOCIATED WITH PURIFIED TYROSINASE ISOZYMES
HEARING, VJ
论文数:
0
引用数:
0
h-index:
0
机构:
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
HEARING, VJ
KORNER, AM
论文数:
0
引用数:
0
h-index:
0
机构:
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
KORNER, AM
PAWELEK, JM
论文数:
0
引用数:
0
h-index:
0
机构:
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
PAWELEK, JM
[J].
JOURNAL OF INVESTIGATIVE DERMATOLOGY,
1982,
79
(01)
: 16
-
18
[6]
DOPACHROME CONVERSION - A POSSIBLE CONTROL POINT IN MELANIN BIOSYNTHESIS
KORNER, AM
论文数:
0
引用数:
0
h-index:
0
机构:
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
KORNER, AM
PAWELEK, J
论文数:
0
引用数:
0
h-index:
0
机构:
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
PAWELEK, J
[J].
JOURNAL OF INVESTIGATIVE DERMATOLOGY,
1980,
75
(02)
: 192
-
195
[7]
SYNTHESIS INVITRO OF 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID BY DOPACHROME CONVERSION FACTOR FROM CLOUDMAN S91 MELANOMA-CELLS
KORNER, AM
论文数:
0
引用数:
0
h-index:
0
机构:
YALE UNIV,SCH MED,DEPT THERAPEUT RADIOL,NEW HAVEN,CT 06510
KORNER, AM
GETTINS, P
论文数:
0
引用数:
0
h-index:
0
机构:
YALE UNIV,SCH MED,DEPT THERAPEUT RADIOL,NEW HAVEN,CT 06510
GETTINS, P
[J].
JOURNAL OF INVESTIGATIVE DERMATOLOGY,
1985,
85
(03)
: 229
-
231
[8]
LAMOREUX ML, 1986, GENETICS, V113, P967
[9]
FUNCTION OF DOPACHROME OXIDOREDUCTASE AND METAL-IONS IN DOPACHROME CONVERSION IN THE EUMELANIN PATHWAY
LEONARD, LJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MED,BOX 485 UMHC,HARVARD ST & E RIVER RD,MINNEAPOLIS,MN 55455
LEONARD, LJ
TOWNSEND, D
论文数:
0
引用数:
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h-index:
0
机构:
UNIV MINNESOTA,DEPT MED,BOX 485 UMHC,HARVARD ST & E RIVER RD,MINNEAPOLIS,MN 55455
TOWNSEND, D
KING, RA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MED,BOX 485 UMHC,HARVARD ST & E RIVER RD,MINNEAPOLIS,MN 55455
KING, RA
[J].
BIOCHEMISTRY,
1988,
27
(16)
: 6156
-
6159
[10]
NEW REGULATORY FACTORS FOR MELANOGENESIS - DEVELOPMENTAL-CHANGES IN NEONATAL MICE OF VARIOUS GENOTYPES
MURRAY, M
论文数:
0
引用数:
0
h-index:
0
机构:
TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843
TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843
MURRAY, M
PAWELEK, JM
论文数:
0
引用数:
0
h-index:
0
机构:
TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843
TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843
PAWELEK, JM
LAMOREUX, ML
论文数:
0
引用数:
0
h-index:
0
机构:
TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843
TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843
LAMOREUX, ML
[J].
DEVELOPMENTAL BIOLOGY,
1983,
100
(01)
: 120
-
126
←
1
2
→
共 18 条
[1]
DECREASED DOPACHROME OXIDOREDUCTASE ACTIVITY IN YELLOW MICE
BARBER, JI
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
BARBER, JI
TOWNSEND, D
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
TOWNSEND, D
OLDS, DP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
OLDS, DP
KING, RA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
UNIV MINNESOTA,SCH DENT,DEPT ORAL PATHOL & GENET,MINNEAPOLIS,MN 55455
KING, RA
[J].
JOURNAL OF HEREDITY,
1985,
76
(01)
: 59
-
60
[2]
DOPACHROME OXIDOREDUCTASE - A NEW ENZYME IN THE PIGMENT PATHWAY
BARBER, JI
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DIV HUMAN & ORAL GENET,MINNEAPOLIS,MN 55455
BARBER, JI
TOWNSEND, D
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DIV HUMAN & ORAL GENET,MINNEAPOLIS,MN 55455
TOWNSEND, D
OLDS, DP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DIV HUMAN & ORAL GENET,MINNEAPOLIS,MN 55455
OLDS, DP
KING, RA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,SCH DENT,DIV HUMAN & ORAL GENET,MINNEAPOLIS,MN 55455
KING, RA
[J].
JOURNAL OF INVESTIGATIVE DERMATOLOGY,
1984,
83
(02)
: 145
-
149
[3]
MELANOGENIC REGULATORY FACTORS IN COATED VESICLES FROM MELANOMA-CELLS
CHAKRABORTY, AK
论文数:
0
引用数:
0
h-index:
0
机构:
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
CHAKRABORTY, AK
MISHIMA, Y
论文数:
0
引用数:
0
h-index:
0
机构:
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
MISHIMA, Y
INAZU, M
论文数:
0
引用数:
0
h-index:
0
机构:
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
INAZU, M
HATTA, S
论文数:
0
引用数:
0
h-index:
0
机构:
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
HATTA, S
ICHIHASHI, M
论文数:
0
引用数:
0
h-index:
0
机构:
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
KOBE UNIV,SCH MED,DEPT DERMATOL,KUSUNOKI CHO 7-5-1,CHUO KU,KOBE 650,JAPAN
ICHIHASHI, M
[J].
JOURNAL OF INVESTIGATIVE DERMATOLOGY,
1989,
93
(05)
: 616
-
620
[4]
HARLEYMASON J, 1950, NATURE, V106, P1036
[5]
NEW REGULATORS OF MELANOGENESIS ARE ASSOCIATED WITH PURIFIED TYROSINASE ISOZYMES
HEARING, VJ
论文数:
0
引用数:
0
h-index:
0
机构:
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
HEARING, VJ
KORNER, AM
论文数:
0
引用数:
0
h-index:
0
机构:
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
KORNER, AM
PAWELEK, JM
论文数:
0
引用数:
0
h-index:
0
机构:
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
PAWELEK, JM
[J].
JOURNAL OF INVESTIGATIVE DERMATOLOGY,
1982,
79
(01)
: 16
-
18
[6]
DOPACHROME CONVERSION - A POSSIBLE CONTROL POINT IN MELANIN BIOSYNTHESIS
KORNER, AM
论文数:
0
引用数:
0
h-index:
0
机构:
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
KORNER, AM
PAWELEK, J
论文数:
0
引用数:
0
h-index:
0
机构:
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
YALE UNIV,SCH MED,DEPT DERMATOL,NEW HAVEN,CT 06510
PAWELEK, J
[J].
JOURNAL OF INVESTIGATIVE DERMATOLOGY,
1980,
75
(02)
: 192
-
195
[7]
SYNTHESIS INVITRO OF 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID BY DOPACHROME CONVERSION FACTOR FROM CLOUDMAN S91 MELANOMA-CELLS
KORNER, AM
论文数:
0
引用数:
0
h-index:
0
机构:
YALE UNIV,SCH MED,DEPT THERAPEUT RADIOL,NEW HAVEN,CT 06510
KORNER, AM
GETTINS, P
论文数:
0
引用数:
0
h-index:
0
机构:
YALE UNIV,SCH MED,DEPT THERAPEUT RADIOL,NEW HAVEN,CT 06510
GETTINS, P
[J].
JOURNAL OF INVESTIGATIVE DERMATOLOGY,
1985,
85
(03)
: 229
-
231
[8]
LAMOREUX ML, 1986, GENETICS, V113, P967
[9]
FUNCTION OF DOPACHROME OXIDOREDUCTASE AND METAL-IONS IN DOPACHROME CONVERSION IN THE EUMELANIN PATHWAY
LEONARD, LJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MED,BOX 485 UMHC,HARVARD ST & E RIVER RD,MINNEAPOLIS,MN 55455
LEONARD, LJ
TOWNSEND, D
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MED,BOX 485 UMHC,HARVARD ST & E RIVER RD,MINNEAPOLIS,MN 55455
TOWNSEND, D
KING, RA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV MINNESOTA,DEPT MED,BOX 485 UMHC,HARVARD ST & E RIVER RD,MINNEAPOLIS,MN 55455
KING, RA
[J].
BIOCHEMISTRY,
1988,
27
(16)
: 6156
-
6159
[10]
NEW REGULATORY FACTORS FOR MELANOGENESIS - DEVELOPMENTAL-CHANGES IN NEONATAL MICE OF VARIOUS GENOTYPES
MURRAY, M
论文数:
0
引用数:
0
h-index:
0
机构:
TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843
TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843
MURRAY, M
PAWELEK, JM
论文数:
0
引用数:
0
h-index:
0
机构:
TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843
TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843
PAWELEK, JM
LAMOREUX, ML
论文数:
0
引用数:
0
h-index:
0
机构:
TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843
TEXAS A&M UNIV,DEPT BIOL,COLLEGE STN,TX 77843
LAMOREUX, ML
[J].
DEVELOPMENTAL BIOLOGY,
1983,
100
(01)
: 120
-
126
←
1
2
→