SEMISYNTHESIS OF A.23187 (CALCIMYCIN) ANALOGS WITH 5-N-AMINO SUBSTITUENTS - THEIR COMPLEXATION OF CALCIUM AND MAGNESIUM

被引：8

作者：

SAMIH, F ^{[1
]}

PRUDHOMME, M ^{[1
]}

DAUPHIN, G ^{[1
]}

JEMINET, G ^{[1
]}

机构：

[1] UNIV CLERMONT FERRAND, CHIM ORGAN BIOL LAB, CNRS, URA 485, F-63177 CLERMONT FERRAND, FRANCE

来源：

TETRAHEDRON | 1990年 / 46卷 / 15期

关键词：

D O I：

10.1016/S0040-4020(01)87824-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The semi-synthesis of A.23187 (calcimycin) analogs 14̃ bearing the respective substituents : 5-NH2, 5-NHCH3, 5-N(CH3)2, 5-NHCOCH3 was carried out. The complexing properties of 14̃ for calcium and magnesium were determined by two-phase experiments (water/toluene-butanol 70:30 W/W) and found to be much weaker than these of A.23187 or X.14885A. There was a discrepancy with theoretical predictions made from model carboxybenzoxazoles. © 1990.

引用

页码：5177 / 5186

页数：10

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