FRACTURE-MECHANICS OF MICROCRYSTALLINE CELLULOSE POWDERS

被引：37

作者：

YORK, P ^{[1
]}

BASSAM, F ^{[1
]}

ROWE, RC ^{[1
]}

ROBERTS, RJ ^{[1
]}

机构：

[1] ICI PLC,DIV PHARMACEUT,MACCLESFIELD SK10 2NA,CHESHIRE,ENGLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 66卷 / 1-3期

关键词：

MICROCRYSTALLINE CELLULOSE POWDER; FRACTURE MECHANICS; CRITICAL STRESS INTENSITY FACTOR; NOTCHED BEAM SPECIMEN; 4-POINT BEAM BENDING;

D O I：

10.1016/0378-5173(90)90393-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A fracture mechanics approach has been successfully applied to determine K(IC), the critical stress intensity factor and a measure of brittleness of materials, using notched beam specimens in four point flexure testing. Seven chemically equivalent microcrystalline cellulose samples have been examined and, based on determined values of K(IC), all samples have been classified as semi-brittle with respect to crack propogation and fracture mechanics. The generally minor differences found in K(IC) values between different suppliers and grades are attributed to alternative processing conditions and variations in solid-state properties.

引用

页码：143 / 148

页数：6

共 19 条

[1]

BASSAM F, 1989, Journal of Pharmacy and Pharmacology, V41, p29P

[2]

BASSAM F, 1988, J PHARM PHARMACOL, V40, pP68

[3]

BROWN EW, 1969, ASTM SPECIAL TECH PU, V410

[4]

FRIEMAN SW, 1983, FRACTURE MECHANICS C, V6, P27

[5] FRACTURE OF RADIALLY EDGE-CRACKED DISKS [J].

KENDALL, K ;

GREGORY, RD .

JOURNAL OF MATERIALS SCIENCE, 1987, 22 (12) :4514-4517

[6]

Mashadi A.B., 1987, J PHARM PHARM S, V39

[7] THE CHARACTERIZATION OF THE MECHANICAL-PROPERTIES OF MICROCRYSTALLINE CELLULOSE - A FRACTURE-MECHANICS APPROACH [J].

MASHADI, AB ;

NEWTON, JM .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1987, 39 (12) :961-965

[8] DETERMINATION OF THE CRITICAL STRESS INTENSITY FACTOR (KIC) OF COMPACTED PHARMACEUTICAL POWDERS BY THE DOUBLE TORSION METHOD [J].

MASHADI, AB ;

NEWTON, JM .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1988, 40 (09) :597-600

[9]

MUNZ D, 1983, FRACTURE MECHANICS C, V6, P1

[10] ELASTIC-MODULUS POROSITY RELATIONSHIP FOR SI3N4 [J].

PHANI, KK ;

NIYOGI, SK .

JOURNAL OF MATERIALS SCIENCE LETTERS, 1987, 6 (05) :511-515

← 1 2 →