ATYPICAL NEUROLEPTIC-LIKE BEHAVIORAL-EFFECTS OF NEUROTENSIN

被引:50
作者
JOLICOEUR, FB
GAGNE, MA
RIVEST, R
DRUMHELLER, A
STPIERRE, S
机构
[1] Department of Psychiatry, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Fleurimont, Que. J1H-5N4
关键词
NEUROTENSIN; APOMORPHINE; N-PROPYLNORAPOMORPHINE; PHYSOSTIGMINE; YAWNING; PENILE ERECTION; STEREOTYPY;
D O I
10.1016/0361-9230(93)90295-M
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To better characterize the neuroleptic-like properties of neurotensin, the dose-related effects of the peptide on the following behavioral phenomena were examined: a) the yawning-penile erection syndrome induced by small doses of the dopamine agonists apomorphine and N-propylnorapomorphine (NPA); b) yawning produced by the anticholinesterase physostigmine, and c) stereotyped climbing and sniffing produced by a larger dose of apomorphine. Several doses of the peptide were injected intraventricularly 30 min prior to drug administration. Results indicate that neurotensin markedly decreased yawning and penile erections produced by both apomorphine and NPA. These effects were seen with relatively small doges (0.9-3.75 mug). Neurotensin also potently decreased physostigmine-induced yawning with the initial inhibitory effect seen with 50 ng of the peptide. Apomorphine-induced climbing was significantly attenuated with 30.0 and 60.0 mug neurotensin, whereas stereotyped sniffing was unaffected, even by doses as large as 120.0 mug. These findings suggest that neurotensin might antagonize dopamine autoreceptors and indicate that the peptide possesses central anticholinergic activity. Furthermore, these results lend support to the hypothesis that neurotensin's profile of central actions resemble that of atypical neuroleptics.
引用
收藏
页码:487 / 491
页数:5
相关论文
共 32 条
[1]   NEUROTENSIN INVITRO MARKEDLY REDUCES THE AFFINITY IN SUBCORTICAL LIMBIC N-PROPYLNORAPOMORPHINE-H-3 BINDING-SITES [J].
AGNATI, LF ;
FUXE, K ;
BENFENATI, F ;
BATTISTINI, N .
ACTA PHYSIOLOGICA SCANDINAVICA, 1983, 119 (04) :459-461
[2]   EVIDENCE FOR DOPAMINE RECEPTOR STIMULATION BY APOMORPHINE [J].
ANDEN, NE ;
RUBENSON, A ;
FUXE, K ;
HOKFELT, T .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1967, 19 (09) :627-&
[3]  
COSTENTIN J, 1983, ADV BIOCHEM PSYCHOPH, P239
[4]   BILATERAL LESIONS OF THE STRIATUM INDUCED WITH 6-HYDROXYDOPAMINE ABOLISH APOMORPHINE-INDUCED YAWNING IN RATS [J].
DOURISH, CT ;
HUTSON, PH .
NEUROPHARMACOLOGY, 1985, 24 (11) :1051-1055
[5]   ANTAGONISM OF THE APOMORPHINE-INDUCED YAWNING BY ATYPICAL NEUROLEPTICS [J].
DUBUC, I ;
PROTAIS, P ;
COLBOC, O ;
COSTENTIN, J .
NEUROPHARMACOLOGY, 1982, 21 (11) :1203-1206
[6]  
ERVIN GN, 1981, NATURE, V291, P73, DOI 10.1038/291073a0
[7]   SCH-23390 DISSOCIATED FROM CONVENTIONAL NEUROLEPTICS IN APOMORPHINE CLIMBING AND PRIMATE ACUTE DYSKINESIA MODELS [J].
GERHARDT, S ;
GERBER, R ;
LIEBMAN, JM .
LIFE SCIENCES, 1985, 37 (25) :2355-2363
[8]   EXTRAPYRAMIDAL REACTIONS AND AMINE METABOLITES IN CEREBROSPINAL-FLUID DURING HALOPERIDOL AND CLOZAPINE TREATMENT OF SCHIZOPHRENIC-PATIENTS [J].
GERLACH, J ;
THORSEN, K ;
FOG, R .
PSYCHOPHARMACOLOGIA, 1975, 40 (04) :341-350
[9]   THE YAWNING-PENILE ERECTION SYNDROME AS A MODEL FOR PUTATIVE DOPAMINE AUTORECEPTOR ACTIVITY [J].
GOWER, AJ ;
BERENDSEN, HHG ;
PRINCEN, MM ;
BROEKKAMP, CLE .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 103 (1-2) :81-89
[10]   THE EFFECTS OF NEUROTENSIN AND [D-TYR11]-NT ON THE HYPERACTIVITY INDUCED BY INTRA-ACCUMBENS ADMINISTRATION OF A POTENT DOPAMINE RECEPTOR AGONIST [J].
JOLICOEUR, FB ;
RIVEST, R ;
STPIERRE, S ;
GAGNE, MA ;
DUMAIS, M .
NEUROPEPTIDES, 1985, 6 (02) :143-156