COLOCALIZATION OF FOS- AND GLUCOCORTICOID RECEPTOR-IMMUNOREACTIVITIES IS PRESENT ONLY IN A VERY RESTRICTED POPULATION OF DORSAL HORN NEURONS OF THE RAT SPINAL-CORD AFTER NOCICEPTIVE STIMULATION

被引：29

作者：

CINTRA, A

MOLANDER, C

FUXE, K

机构：

[1] Department of Neuroscience, Karolinska Institute, S-171 77 Stockholm

来源：

BRAIN RESEARCH | 1993年 / 632卷 / 1-2期

关键词：

GLUCOCORTICOID RECEPTOR; CORTICOSTEROID; PAIN; IMMUNOCYTOCHEMISTRY; IMMEDIATE EARLY GENE; C-FIBER STIMULATION; NOCICEPTION; PRIMARY SENSORY NEURON;

D O I：

10.1016/0006-8993(93)91172-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Immunocytochemical techniques were used to study the colocalization of proto-oncogene c-fos protein (Fos)-like immunoreactivity and of glucocorticoid receptor immunoreactivity in the spinal cord dorsal horn of adult male rats after nociceptive stimulation. About 5-10% of the stimulus evoked Fos-immunoreactive profiles colocalized glucocorticoid receptor immunoreactivity. The results suggest the possibility of a corticosteroid action in a small neuronal population of the dorsal horn implicated in processing nociceptive inputs.

引用

页码：334 / 338

页数：5

共 31 条

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