ACRYLIC-ACID OXIDATION AND TISSUE-TO-BLOOD PARTITION-COEFFICIENTS IN RAT-TISSUES

被引：11

作者：

BLACK, KA

FINCH, L

机构：

[1] Toxicology Department, Rohm and Haas Company, Spring House, PA 19477-0904

来源：

TOXICOLOGY LETTERS | 1995年 / 78卷 / 01期

关键词：

ACRYLIC ACID; BETA-OXIDATION; RATS; TISSUE SLICES; PARTITION COEFFICIENT;

D O I：

10.1016/0378-4274(94)03233-W

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

We report rates of acrylic acid (AA) oxidation and tissue/blood partition coefficients in rat tissues. AA oxidation in Fischer 344 rat kidney and liver slices was described by saturable kinetics with maximal velocities of about 4 and 2 mu mol/h/g, respectively. AA oxidation rates in 11 additional tissues were 40% or less than in liver. AA oxidation rates in Sprague-Dawley rat liver and kidney were similar to those in Fischer rats. Partition coefficients varied within a narrow range, suggesting that a tissue's contribution to systemic detoxification of AA will depend much more strongly on its rate of AA oxidation and the proportion of the cardiac output that it receives.

引用

页码：73 / 78

页数：6

共 12 条

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