HIGH-INCIDENCE OF XXY AND XYY MALES AMONG THE OFFSPRING OF FEMALE CHIMERAS FROM EMBRYONIC STEM-CELLS

被引：26

作者：

BRONSON, SK ^{[1
]}

SMITHIES, O ^{[1
]}

MASCARELLO, JT ^{[1
]}

机构：

[1] CHILDRENS HOSP & HLTH CTR,GENET LAB,SAN DIEGO,CA 92123

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 08期

关键词：

SEX CHROMOSOMES; KARYOTYPE; ANEUPLOIDY; XX/XY FEMALES;

D O I：

10.1073/pnas.92.8.3120

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Injecting male embryonic stem cells into the blastocoel of female embryos occasionally produces female chimeras capable of transmitting the embryonic stem cell genome. In our experiments several embryonic stem cell-derived male offspring from female chimeras were observed to be infertile. Karyotypic analysis of these infertile animals revealed aneuploidy. We examined the karyotypes of an additional 14 offspring not selected for infertility (3 females and 11 males) that had received the embryonic stem cell genome from 5 transmitting female chimeras. The 3 females and 5 of the males had normal karyotypes. Six of the males exhibited nonmosaic aneuploidy, which included four XXY karyotypes, one XYY karyotype, and an X,i(Y) karyotype. The high incidence of XXY and XYY males supports previous evidence for aberrant pairing and segregation of X and Y chromosomes when they are present in oocytes.

引用

页码：3120 / 3123

页数：4

共 26 条

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