THE INITIAL VASODILATION AND THE LATER VASOCONSTRICTION OF ENDOTHELIN-1 ARE SELECTIVE TO SPECIFIC VASCULAR BEDS

被引：14

作者：

HOFFMAN, A

GROSSMAN, E

OHMAN, KP

MARKS, E

KEISER, HR

机构：

[1] The Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, Bethesda, MD

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 10期

关键词：

Blood flow; Endothelin; Vascular resistance;

D O I：

10.1093/ajh/3.10.789

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The regional hemodynamic effects of endothelin-1 (ET-1) were studied in Wistar-Kyoto rats. Endothelin-1 caused a transient increase in blood flow in the carotid and femoral arteries but a decrease in flow in the renal and mesenteric arteries. The resistance in the carotid and femoral beds decreased while it increased in the renal and mesenteric beds. Subsequently there was a variable increase in resistance in all vascular beds with a maximal increase in the renal bed. Thus, ET-1 initially causes a selective vasorelaxation in musculocutaneous beds but not in visceral beds; the cause of this selectivity is unknown. Am J Hypertens 1990;3:789-791. © 1990, American Journal of Hypertension, Ltd. All rights reserved.

引用

页码：789 / 791

页数：3

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