SERUM BACTERICIDAL ACTIVITY AFTER ADMINISTRATION OF 4 CEPHALOSPORINS IN HEALTHY-VOLUNTEERS

被引：6

作者：

LEMMEN, S ^{[1
]}

KROPEC, A ^{[1
]}

ENGELS, I ^{[1
]}

BUSSE, A ^{[1
]}

DASCHNER, FD ^{[1
]}

机构：

[1] UNIV HOSP FREIBURG,HOSP EPIDEMIOL,D-79106 FREIBURG,GERMANY

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 1993年 / 12卷 / 11期

关键词：

D O I：

10.1007/BF02000408

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Serum bactericidal activity (SBA) was determined against ten strains each of Staphylococcus aureus, Klebsiella pneumoniae, Proteus vulgaris and Enterobacter cloacae in six volunteers 1 h and 4 h after intravenous infusion of 1 g and 2 g cefotaxime and cefmenoxime, and 2 g flomoxef, and against ten strains of Pseudomonas aeruginosa after infusion of 1 g and 2 g ceftazidime. Flomoxef showed the highest SBA against methicillin-susceptible Staphylococcus aureus. All cephalosporins had high SBA against gramnegative rods. Cefotaxime had the highest SBA against Klebsiella pneumoniae and Enterobacter cloacae. The SBA against Pseudomonas aeruginosa after 1 g and 2 g doses of ceftazidime was very similar.

引用

页码：856 / 860

页数：5

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