EVALUATION OF GENOTOXICITY OF BROMATE ION PRODUCED DURING OZONATION

被引：10

作者：

ONO, Y

SOMIYA, I

MOHRI, S

机构：

[1] Department of Environmental & Sanitary Engineering, Kyoto University, Kyoto 606-01, Yoshida-Honmachi, Sakyo-ku

来源：

OZONE-SCIENCE & ENGINEERING | 1994年 / 16卷 / 05期

关键词：

OZONE; GENOTOXICITY; OZONE BY-PRODUCTS; BROMATE ION; UMU TEST; LIVER S9 FRACTION; ANIMAL TESTS; SH COMPOUNDS;

D O I：

10.1080/01919512.1994.10555751

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Bromate ion formation during ozonation processes in water works is regarded as an issue of great interest because of its potential for carcinogenicity. In this research, genotoxicity of bromate ion was investigated by the umu- test using Salmonella typhimurium TA1535/pSK1002. The time-course study showed that the umuC gene related to error-prone repair of damaged DNA was induced by bromate ion after 12 hours exposure of the test strain. However, a further study revealed that this induction was inactivated by metabolism with rat liver microsome when bromate ion concentration was less than 0.88 mg BrO3-/mg as protein of the S9 fraction. This inactivation was assumed to depend on -SH compounds in liver microsome.

引用

页码：443 / 453

页数：11

共 11 条

[1] METABOLISM OF POTASSIUM BROMATE IN RATS .1. INVIVO STUDIES [J].

FUJII, M ;

OIKAWA, K ;

SAITO, H ;

FUKUHARA, C ;

ONOSAKA, S ;

TANAKA, K .

CHEMOSPHERE, 1984, 13 (11) :1207-1212

[2] ON THE DISAPPEARANCE OF CHLORINE IN SEA-WATER [J].

HAAG, WR .

WATER RESEARCH, 1981, 15 (07) :937-940

[3] TOXICITY AND CARCINOGENICITY OF POTASSIUM BROMATE - A NEW RENAL CARCINOGEN [J].

KUROKAWA, Y ;

MAEKAWA, A ;

TAKAHASHI, M ;

HAYASHI, Y .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1990, 87 :309-335

[4]

Miller JF., 1972, EXPT MOL GENETICS

[5] SOS-INDUCING ACTIVITY OF CHEMICAL CARCINOGENS AND MUTAGENS IN SALMONELLA-TYPHIMURIUM TA1535/PSK1002 - EXAMINATION WITH 151 CHEMICALS [J].

NAKAMURA, S ;

ODA, Y ;

SHIMADA, T ;

OKI, I ;

SUGIMOTO, K .

MUTATION RESEARCH, 1987, 192 (04) :239-246

[6] EVALUATION OF THE NEW SYSTEM (UMU-TEST) FOR THE DETECTION OF ENVIRONMENTAL MUTAGENS AND CARCINOGENS [J].

ODA, Y ;

NAKAMURA, S ;

OKI, I ;

KATO, T ;

SHINAGAWA, H .

MUTATION RESEARCH, 1985, 147 (05) :219-229

[7]

RICE RG, 1992, OZONE NEWS, V20, P8

[8] METABOLISM OF POTASSIUM BROMATE IN RATS .2. INVITRO STUDIES [J].

TANAKA, K ;

OIKAWA, K ;

FUKUHARA, C ;

SAITO, H ;

ONOSAKA, S ;

MIN, KS ;

FUJII, M .

CHEMOSPHERE, 1984, 13 (11) :1213-1219

[9]

YAMADA H, 1993, OZONE WATER WASTEWAT, V1

[10]

1987, IARC MONOGRAPHS S7, V1, P70

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