OPTIMAL INTRAVENOUS DOSING STRATEGIES FOR SEDATIVES AND ANALGESICS IN THE INTENSIVE-CARE UNIT

Critically ill patients typically receive intravenous opioids and sedative-hypnotics in the intensive care unit (ICU) to minimize physical and psychological discomfort. Inadequate dosing of sedatives and analgesics in the ICU may lead to unwanted agitation, decannulation, and cardiopulmonary instability. Excessive dosing of these medications may lead to respiratory depression, systemic hypotension, and prolonged sedation after discontinuation. This article attempts to define intravenous dosing strategies for opioids and sedative-hypnotics commonly administered to ICU patients.