VASOPRESSIN-DEFICIENT PARAVENTRICULAR MAGNOCELLULAR NEURONS OF HOMOZYGOUS BRATTLEBORO RATS SYNTHESIZE NEUROPEPTIDE-Y

被引：12

作者：

KAGOTANI, Y

HISANO, S

TSURUO, Y

DAIKOKU, S

CHIHARA, K

机构：

[1] UNIV TOKUSHIMA,SCH MED,DEPT ANAT,TOKUSHIMA 770,JAPAN

[2] KOBE UNIV,SCH MED,INT CTR MED RES,KOBE 650,JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 112卷 / 01期

关键词：

Brattleboro rat; Hypothalamus; Neuropeptide Y; Neurosecretory neuron; Paraventricular nucleus;

D O I：

10.1016/0304-3940(90)90318-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Immunohistochemical study was carried out to determine whether neuropeptide Y (NPY), which was only found in certain experimental procedures in arginine vasopressin (AVP)-containing neurons of the magnocellular paraventricular nucleus, might also be synthesized in AVP-deficient homozygous Brattleboro (BB) rats. After an intraventricular colchicine administration, NPY was found in many AVP-deficient non-oxytocinergic magnocellular neurons of the paraventricular and supraoptic nuclei in BB rats, but not in suprachiasmatic nucleus neurons. The results suggest that the NPY synthesis is a phenotype of magnocellular non-oxytocinergic neurosecretory neurons and occurs independently from the synthesis of AVP. © 1990.

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页码：37 / 42

页数：6

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