DEPENDENCE OF KIDNEY MORPHOGENESIS ON THE EXPRESSION OF NERVE GROWTH-FACTOR RECEPTOR

被引：194

作者：

SARIOLA, H

SAARMA, M

SAINIO, K

ARUMAE, U

PALGI, J

VAAHTOKARI, A

THESLEFF, I

KARAVANOV, A

机构：

[1] ACAD SCI ESSSR, INST CHEM PHYS & BIOPHYS, 200103 TALLINN, ESTONIA, USSR

[2] UNIV HELSINKI, INST PEDODONT & ORTHODONT, SF-00100 HELSINKI 10, FINLAND

[3] UNIV HELSINKI, DEPT PATHOL, SF-00100 HELSINKI 10, FINLAND

[4] UNIV HELSINKI, INST BIOTECHNOL, SF-00100 HELSINKI 10, FINLAND

来源：

SCIENCE | 1991年 / 254卷 / 5031期

关键词：

D O I：

10.1126/science.1658930

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nerve growth factor receptor (NGFR) serves as the binding site for the neurotrophic growth factors. Although NGFR has been found in several embryonic tissues outside the nervous system, the function of NGFR in embryogenesis of non-neuronal organs remains unknown. NGFR is transiently synthesized by embryonic rat kidney and disappears from nephrons upon their terminal differentiation. Anti-sense oligonucleotide inhibition of NGFR expression inhibits kidney morphogenesis. Therefore, NGFR is required not only for development of the nervous system, but also for differentiation of the kidney tubules.

引用

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页码：571 / 573

页数：3

相关论文

共 41 条

[1] TROPHIC FACTORS AND NEURONAL SURVIVAL [J].

BARDE, YA .

NEURON, 1989, 2 (06) :1525-1534

[2]

BENGTSTROM M, IN PRESS NUCLEIC ACI

[3] DETECTION OF DNA-BINDING PROTEINS BY PROTEIN BLOTTING [J].

BOWEN, B ;

STEINBERG, J ;

LAEMMLI, UK ;

WEINTRAUB, H .

NUCLEIC ACIDS RESEARCH, 1980, 8 (01) :1-20

[4] IMMUNOHISTOCHEMICAL ANALYSIS OF NERVE GROWTH-FACTOR RECEPTOR EXPRESSION IN NORMAL AND MALIGNANT HUMAN-TISSUES [J].

CHESA, PG ;

RETTIG, WJ ;

THOMSON, TM ;

OLD, LJ ;

MELAMED, MR .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1988, 36 (04) :383-389

[5] BINDING CHARACTERISTICS AND APPARENT MOLECULAR-SIZE OF DETERGENT-SOLUBILIZED NERVE GROWTH-FACTOR RECEPTOR OF SYMPATHETIC-GANGLIA [J].

COSTRINI, NV ;

BRADSHAW, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (07) :3242-3245

[6]

ENFORS P, 1990, NEURON, V5, P511

[7] DEVELOPMENTAL AND REGIONAL EXPRESSION OF BETA-NERVE GROWTH-FACTOR RECEPTOR MESSENGER-RNA IN THE CHICK AND RAT [J].

ERNFORS, P ;

HALLBOOK, F ;

EBENDAL, T ;

SHOOTER, EM ;

RADEKE, MJ ;

MISKO, TP ;

PERSSON, H .

NEURON, 1988, 1 (10) :983-996

[8] THE NERVE GROWTH-FACTOR RECEPTOR GENE IS EXPRESSED IN BOTH NEURONAL AND NONNEURONAL TISSUES IN THE HUMAN FETUS [J].

ERNFORS, P ;

WETMORE, C ;

ERIKSDOTTERNILSSON, M ;

BYGDEMAN, M ;

STROMBERG, I ;

OLSON, L ;

PERSSON, H .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 1991, 9 (01) :57-66

[9] MOLECULAR-CLONING AND NEUROTROPHIC ACTIVITIES OF A PROTEIN WITH STRUCTURAL SIMILARITIES TO NERVE GROWTH-FACTOR - DEVELOPMENTAL AND TOPOGRAPHICAL EXPRESSION IN THE BRAIN [J].

ERNFORS, P ;

IBANEZ, CF ;

EBENDAL, T ;

OLSON, L ;

PERSSON, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5454-5458

[10] SYNTHESIS OF DNA VIA DEOXYNUCLEOSIDE H-PHOSPHONATE INTERMEDIATES [J].

FROEHLER, BC ;

NG, PG ;

MATTEUCCI, MD .

NUCLEIC ACIDS RESEARCH, 1986, 14 (13) :5399-5407

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