NEUROTROPHIN INDUCED 2ND MESSENGER RESPONSES IN RAT-BRAIN SYNAPTOSOMES

被引：48

作者：

KNIPPER, M ^{[1
]}

BECK, A ^{[1
]}

RYLETT, J ^{[1
]}

BREER, H ^{[1
]}

机构：

[1] UNIV STUTTGART HOHENHEIM, INST ZOOPHYSIOL, STUTTGART, GERMANY

来源：

NEUROREPORT | 1993年 / 4卷 / 05期

关键词：

NGF; BDNF; CAMP; IP(3); NGFR(TRK); SYNAPTOSOMES; HIPPOCAMPUS;

D O I：

10.1097/00001756-199305000-00005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

NEUROTROPHINS (NGF, BDNF) elicit significant elevation of cAMP as well as IP3-concentrations in either membrane preparations or intact isolated nerve endings from rat brain hippocampus. The induced second messenger responses in membrane preparations were detectable in the subsecond time range. The IP3-level reached a maximum after a few hundred ms; whereas the cAMP-level continued to rise even after several seconds. The IP3-response but not the cAMP-signal was inhibited in the presence of the tyrosine kinase blocker K252a, suggesting that the two second messenger cascades were triggered via different mechanisms. The results suggest that neurotrophins may induce short-term effects in nerve terminals via second messenger pathways.

引用

页码：483 / 486

页数：4

共 25 条

[1] BRAIN-DERIVED NEUROTROPHIC FACTOR INCREASES SURVIVAL AND DIFFERENTIATED FUNCTIONS OF RAT SEPTAL CHOLINERGIC NEURONS IN CULTURE [J].

ALDERSON, RF ;

ALTERMAN, AL ;

BARDE, YA ;

LINDSAY, RM .

NEURON, 1990, 5 (03) :297-306

[2] RAPID ACTIVATION OF ALTERNATIVE 2ND MESSENGER PATHWAYS IN OLFACTORY CILIA FROM RATS BY DIFFERENT ODORANTS [J].

BOEKHOFF, I ;

TAREILUS, E ;

STROTMANN, J ;

BREER, H .

EMBO JOURNAL, 1990, 9 (08) :2453-2458

[3]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[4] CALCIUM-DEPENDENT NERVE GROWTH FACTOR-STIMULATED HYDROLYSIS OF PHOSPHOINOSITIDES IN PC12 CELLS [J].

CONTRERAS, ML ;

GUROFF, G .

JOURNAL OF NEUROCHEMISTRY, 1987, 48 (05) :1466-1472

[5] THE TRK TYROSINE PROTEIN-KINASE MEDIATES THE MITOGENIC PROPERTIES OF NERVE GROWTH-FACTOR AND NEUROTROPHIN-3 [J].

CORDONCARDO, C ;

TAPLEY, P ;

JING, SQ ;

NANDURI, V ;

OROURKE, E ;

LAMBALLE, F ;

KOVARY, K ;

KLEIN, R ;

JONES, KR ;

REICHARDT, LF ;

BARBACID, M .

CELL, 1991, 66 (01) :173-183

[6] NERVE GROWTH-FACTOR ACTION IS MEDIATED BY CYCLIC AMP- AND CA-+2 PHOSPHOLIPID-DEPENDENT PROTEIN-KINASES [J].

CREMINS, J ;

WAGNER, JA ;

HALEGOUA, S .

JOURNAL OF CELL BIOLOGY, 1986, 103 (03) :887-893

[7] A RAPID METHOD FOR ISOLATION OF SYNAPTOSOMES ON PERCOLL GRADIENTS [J].

DUNKLEY, PR ;

JARVIE, PE ;

HEATH, JW ;

KIDD, GJ ;

ROSTAS, JAP .

BRAIN RESEARCH, 1986, 372 (01) :115-129

[8] DEVELOPMENTAL AND REGIONAL EXPRESSION OF BETA-NERVE GROWTH-FACTOR RECEPTOR MESSENGER-RNA IN THE CHICK AND RAT [J].

ERNFORS, P ;

HALLBOOK, F ;

EBENDAL, T ;

SHOOTER, EM ;

RADEKE, MJ ;

MISKO, TP ;

PERSSON, H .

NEURON, 1988, 1 (10) :983-996

[9] RAPID ACTIVATION OF TYROSINE-HYDROXYLASE IN RESPONSE TO NERVE GROWTH-FACTOR [J].

GREENE, LA ;

SEELEY, PJ ;

RUKENSTEIN, A ;

DIPIAZZA, M ;

HOWARD, A .

JOURNAL OF NEUROCHEMISTRY, 1984, 42 (06) :1728-1734

[10]

HALEGOUA S, 1991, CURR TOP MICROBIOL, V165, P119

← 1 2 3 →