SYNTHESIS OF POLY(GAMMA-BENZYL L-GLUTAMATE) POLY(ETHYLENE OXIDE) DIBLOCK COPOLYMER ENDCAPPED WITH SUGAR MOIETY FOR CELL-SPECIFIC BIOMATERIALS

被引：9

作者：

CHO, CS

CHUNG, SJ

GOTO, M

KOBAYASHI, A

AKAIKE, T

机构：

[1] CHONNAM NATL UNIV, DEPT POLYMER ENGN, KWANGJU 500757, SOUTH KOREA

[2] KANAGAWA ACAD SCI & TECHNOL, TAKATSU KU, KANAGAWA 213, JAPAN

[3] TOKYO INST TECHNOL, FAC BIOSCI & BIOTECHNOL, MIDORI KU, KANAGAWA 227, JAPAN

来源：

CHEMISTRY LETTERS | 1994年 / 10期

关键词：

D O I：

10.1246/cl.1994.1817

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

AB block copolymers consisting of poly(gamma-benzyl L-glutamate)(PBLG) as component A and poly(ethylene oxide) as component B were prepared containing [O-beta-D-galactopyranosyl-( 1 --> 4)]-D-gluconamide or [O-alpha-D-glucopyranosyl-(1 --> 4)]-D-gluconamide, From the circular dichroism measurements in solution state as well as infrared measurements in solid state, it was found that they had a-helical structure in both states as same as for the PBLG homopolymer. From adhesion of hepatocytes to the copolymer in vitro, it was found that lactose-carrying PBLG/PEO block copolymer had about 80% of adhesion within 2 h.

引用

页码：1817 / 1820

页数：4

共 15 条

[1] MEMBRANE GLYCOPROTEINS AND RECOGNITION PHENOMENA [J].